Abstract
Background
Cancer and its treatment represent major stressors requiring that patients make multiple adaptations. Despite evidence that poor adaptation to stressors is associated with more distress and negative affect (NA), neuroimmune dysregulation and poorer health outcomes, current understanding is very limited of how NA covaries with central nervous system changes to account for these associations.
Methods
NA was correlated with brain metabolic activity using 18F‐fluorodeoxyglucose positron emission tomography/computed tomography (18F‐FDG PET/CT) in several regions of interest in 61 women with metastatic breast cancer. Patients underwent 18F‐FDG PET/CT and completed an assessment of NA using the Brief Symptom Inventory.
Results
Regression analyses revealed that NA was significantly negatively correlated with the standardized uptake value ratio of the insula, thalamus, hypothalamus, ventromedial prefrontal cortex, and lateral prefrontal cortex. Voxel‐wise correlation analyses within these 5 regions of interest demonstrated high left‐right symmetry and the highest NA correlations with the anterior insula, thalamus (medial and ventral portion), lateral prefrontal cortex (right Brodmann area 9 [BA9], left BA45, and right and left BA10 and BA8), and ventromedial prefrontal cortex (bilateral BA11).
Conclusions
The regions of interest most strongly negatively associated with NA represent key areas for successful adaptation to stressors and may be particularly relevant in patients with metastatic breast cancer who are dealing with multiple challenges of cancer and its treatment.
This work is an initial step in identifying brain regions that may underlie successful adaptation to the personal challenges of cancer and its treatment. Understanding how central nervous system‐mediated adaptation processes relate to both negative affect and neuroimmune regulation could illuminate mechanisms to explain the documented effects of stress and stress management interventions on health outcomes in patients with cancer.
