Neuronal RAGE expression modulates severity of injury following transient focal cerebral ischemia

Benjamin G Hassid; M. Nathan Nair; Andrew F Ducruet; Marc L Otten; Ricardo J Komotar; David J Pinsky; Ann Marie Schmidt; Shi Fang Yan; E. Sander Connolly

doi:10.1016/j.jocn.2007.12.011

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Neuronal RAGE expression modulates severity of injury following transient focal cerebral ischemia

Journal article

Peer reviewed

Neuronal RAGE expression modulates severity of injury following transient focal cerebral ischemia

Benjamin G Hassid, M. Nathan Nair, Andrew F Ducruet, Marc L Otten, Ricardo J Komotar, David J Pinsky, Ann Marie Schmidt, Shi Fang Yan and E. Sander Connolly

Journal of clinical neuroscience, Vol.16(2), pp.302-306

2009

DOI: https://doi.org/10.1016/j.jocn.2007.12.011

PMID: 19071026

Abstract

Stroke

Inflammation

Reperfusion

RAGE

Ischemia

Murine

Inflammation has a significant role in the neurological injury that follows stroke. The receptor for advanced-glycation end products (RAGE) is a multiligand member of the immunoglobulin superfamily that has been implicated in multiple neuronal and inflammatory stress processes. To directly test the role of neuronal RAGE in stroke, we employed two cohorts of transgenic mice, one over-expressing full-length functional human RAGE in neurons, and the other a human RAGE transgene in which deletion of the cytoplasmic domain of the receptor in neurons suppresses signal transduction stimulated by ligands (referred to as dominant negative or DN-RAGE). We found a statistically significant increase in stroke volume in the RAGE over-expressing cohort compared to normal controls, and a trend towards decreased stroke volume in the DN RAGE cohort. These results indicate that RAGE signaling directly contributes to pathology in cerebral ischemia.

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Collaboration types: Domestic collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.16 Phytochemicals; 3.16.614 Advanced Glycation End Products
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior

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Details

Title: Neuronal RAGE expression modulates severity of injury following transient focal cerebral ischemia
Creators: Benjamin G Hassid - Department of Neurological Surgery, 710 West 168th Street, Room 431, Columbia University, New York, New York 10032, USA
M. Nathan Nair - Department of Neurological Surgery, University of Washington, Seattle, Washington, USA
Andrew F Ducruet - Department of Neurological Surgery, 710 West 168th Street, Room 431, Columbia University, New York, New York 10032, USA
Marc L Otten - Department of Neurological Surgery, 710 West 168th Street, Room 431, Columbia University, New York, New York 10032, USA
Ricardo J Komotar - Department of Neurological Surgery, 710 West 168th Street, Room 431, Columbia University, New York, New York 10032, USA
David J Pinsky - Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA
Ann Marie Schmidt - Department of Surgery, Columbia University, New York, New York, USA
Shi Fang Yan - Department of Surgery, Columbia University, New York, New York, USA
E. Sander Connolly - Department of Neurological Surgery, 710 West 168th Street, Room 431, Columbia University, New York, New York 10032, USA
Publication Details: Journal of clinical neuroscience, Vol.16(2), pp.302-306
Publisher: Elsevier Ltd
Academic Unit: Miller School of Medicine; UMMG Dept of Neurological Surgery
Language: English
Resource Type: Journal article
PMID: 19071026
Record Identifier: 991031559908302976