New designs for DNA bases: Expanded DNAs and oligofluorosides

Eric T Kool; Haige Lu; Su Jeong Kim; Samuel Tan; James N Wilson; Jianmin Gao; Haibo Liu

doi:10.1093/nass/nrl008

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Journal article

New designs for DNA bases: Expanded DNAs and oligofluorosides

Eric T Kool, Haige Lu, Su Jeong Kim, Samuel Tan, James N Wilson, Jianmin Gao and Haibo Liu

Nucleic Acids Symposium Series, Vol.50(1), pp.15-16

2006-11

DOI: https://doi.org/10.1093/nass/nrl008

Abstract

Properties and applications of two new classes of DNA base replacements are described. The first class is size-expanded DNA bases; these are benzo-homologous versions of A, C, T, G that yield base pairs 2.4 Angstroms larger than natural pairs. New studies have explored the ability of expanded DNA base pairs to be replicated by DNA polymerase enzymes. The second class of DNA-like molecules described here are “oligodeoxyfluorosides” (ODFs), which are deoxyribose-phosphate oligomers in which all nucleobases are replaced by hydrocarbon and heterocyclic fluorophores. These compounds have been prepared in large libraries and have been screened for unusual fluorescence and sensing properties.

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Title: New designs for DNA bases: Expanded DNAs and oligofluorosides
Creators: Eric T Kool - Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Haige Lu - Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Su Jeong Kim - Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Samuel Tan - Department of Chemistry, Stanford University, Stanford, CA 94305, USA
James N Wilson - Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Jianmin Gao - Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Haibo Liu - Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Publication Details: Nucleic Acids Symposium Series, Vol.50(1), pp.15-16
Publisher: Oxford University Press
Academic Unit: A&S - Chemistry; College of A&S
Language: English
Resource Type: Journal article
Record Identifier: 991031614975302976