Normal Taste Acceptance and Preference of PANX1 Knockout Mice

Michael G Tordoff; Tiffany R Aleman; Hillary T Ellis; Makoto Ohmoto; Ichiro Matsumoto; Val I Shestopalov; Claire H Mitchell; J Kevin Foskett; Rachel L Poole

doi:10.1093/chemse/bjv025

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Normal Taste Acceptance and Preference of PANX1 Knockout Mice

Journal article

Open access

Peer reviewed

Normal Taste Acceptance and Preference of PANX1 Knockout Mice

Michael G Tordoff, Tiffany R Aleman, Hillary T Ellis, Makoto Ohmoto, Ichiro Matsumoto, Val I Shestopalov, Claire H Mitchell, J Kevin Foskett and Rachel L Poole

Chemical senses, Vol.40(7), pp.453-459

2015-09

DOI: https://doi.org/10.1093/chemse/bjv025

PMCID: PMC4635636

PMID: 25987548

Abstract

Connexins - deficiency

Mice, Inbred C57BL

Nerve Tissue Proteins - deficiency

Nerve Tissue Proteins - analysis

Male

Taste - physiology

Connexins - metabolism

Mice, Knockout

Nerve Tissue Proteins - metabolism

Taste Perception - physiology

Animals

Adenosine Triphosphate - metabolism

Female

Mice

Connexins - analysis

Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.

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Collaboration types: Domestic collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.220 Smell & Taste Science; 3.220.1242 Aspartame
Web Of Science research areas: Behavioral Sciences; Food Science & Technology; Neurosciences; Physiology
ESI research areas: Neuroscience & Behavior

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Details

Title: Normal Taste Acceptance and Preference of PANX1 Knockout Mice
Creators: Michael G Tordoff - Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA, tordoff@monell.org
Tiffany R Aleman - Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
Hillary T Ellis - Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
Makoto Ohmoto - Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
Ichiro Matsumoto - Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
Val I Shestopalov - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33136, USA
Claire H Mitchell - Department of Anatomy and Cell Biology, University of Pennsylvania, 240 South 40th Street, PA 19104, USA, and
J Kevin Foskett - Department of Physiology, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Rachel L Poole - Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
Publication Details: Chemical senses, Vol.40(7), pp.453-459
Publisher: England
Grant note: DC-12538 / NIDCD NIH HHS P30 DC011735 / NIDCD NIH HHS DK-46791 / NIDDK NIH HHS T32 DC000014 / NIDCD NIH HHS EY021517 / NEI NIH HHS R01 DC012538 / NIDCD NIH HHS R01 EY015537 / NEI NIH HHS R01 EY021517 / NEI NIH HHS
Academic Unit: Miller School of Medicine; UMMG Department of Ophthalmology
Language: English
Resource Type: Journal article
PMID: 25987548
PMCID: PMC4635636
Record Identifier: 991031577291502976