Nucleic acid sensing by T cells initiates Th2 cell differentiation

Takayuki Imanishi; Chitose Ishihara; Mohamed El Sherif Gadelhaq Badr; Akiko Hashimoto-Tane; Yayoi Kimura; Taro Kawai; Osamu Takeuchi; Ken J Ishii; Shun'ichiro Taniguchi; Tetsuo Noda; Hisashi Hirano; Frank Brombacher; Glen N Barber; Shizuo Akira; Takashi Saito

doi:10.1038/ncomms4566

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Nucleic acid sensing by T cells initiates Th2 cell differentiation

Journal article

Open access

Peer reviewed

Nucleic acid sensing by T cells initiates Th2 cell differentiation

Takayuki Imanishi, Chitose Ishihara, Mohamed El Sherif Gadelhaq Badr, Akiko Hashimoto-Tane, Yayoi Kimura, Taro Kawai, Osamu Takeuchi, Ken J Ishii, Shun'ichiro Taniguchi, Tetsuo Noda, …

Nature communications, Vol.5(1), pp.3566-3566

2014-04-10

DOI: https://doi.org/10.1038/ncomms4566

PMID: 24717539

Abstract

T-Lymphocytes, Helper-Inducer - metabolism

Enzyme-Linked Immunosorbent Assay

Mice, Inbred C57BL

Th2 Cells - cytology

Nucleic Acids - metabolism

Th2 Cells - metabolism

Microscopy, Confocal

Animals

Chromatin Immunoprecipitation

RNA Interference

T-Lymphocytes, Helper-Inducer - cytology

Mice

Cell Differentiation - physiology

Real-Time Polymerase Chain Reaction

While T-cell responses are directly modulated by Toll-like receptor (TLR) ligands, the mechanism and physiological function of nucleic acids (NAs)-mediated T cell costimulation remains unclear. Here we show that unlike in innate cells, T-cell costimulation is induced even by non-CpG DNA and by self-DNA, which is released from dead cells and complexes with antimicrobial peptides or histones. Such NA complexes are internalized by T cells and induce costimulatory responses independently of known NA sensors, including TLRs, RIG-I-like receptors (RLRs), inflammasomes and STING-dependent cytosolic DNA sensors. Such NA-mediated costimulation crucially induces Th2 differentiation by suppressing T-bet expression, followed by the induction of GATA-3 and Th2 cytokines. These findings unveil the function of NA sensing by T cells to trigger and amplify allergic inflammation.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.609 Toll-like Receptors
Web Of Science research areas: Immunology
ESI research areas: Immunology

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Title: Nucleic acid sensing by T cells initiates Th2 cell differentiation
Creators: Takayuki Imanishi - Laboratory for Cell Signaling, RCAI, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan
Chitose Ishihara - Laboratory for Cell Signaling, RCAI, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan
Mohamed El Sherif Gadelhaq Badr - Laboratory for Cell Signaling, RCAI, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan
Akiko Hashimoto-Tane - Laboratory for Cell Signaling, RCAI, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan
Yayoi Kimura - Graduate School of Medical Life Sciences, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan
Taro Kawai - 1] Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan
Osamu Takeuchi - 1] Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan
Ken J Ishii - 1] Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Ibaraki, Osaka 567-0085, Japan Laboratories of Vaccine Science, WPI Immunology Frontier Research, Osaka University, Suita, Osaka 565-0871, Japan
Shun'ichiro Taniguchi - Department of Molecular Oncology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, Nagano 390-8621, Japan
Tetsuo Noda - Department of Cell Biology, Cancer Research Institute of the Japanese Foundation of Cancer Research, Toshima-ku, Tokyo 170-8455, Japan
Hisashi Hirano - Graduate School of Medical Life Sciences, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan
Frank Brombacher - International Center for Genetic Engineering and Biotechnology, Cape Town Component and Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Science, Division of Immunology, University of Cape Town, Cape Town, South Africa
Glen N Barber - Department of Cell Biology and the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Shizuo Akira - Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan
Takashi Saito - 1] Laboratory for Cell Signaling, RCAI, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan Laboratory for Cell Signaling, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan
Publication Details: Nature communications, Vol.5(1), pp.3566-3566
Publisher: England
Academic Unit: Leadership Department; Miller School of Medicine; Cell Biology Research
Language: English
Resource Type: Journal article
PMID: 24717539
Record Identifier: 991031561440202976