Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population

Alberto R Ramos; Wassim Tarraf; Tatjana Rundek; Susan Redline; William K Wohlgemuth; Jose S Loredo; Ralph L Sacco; David J Lee; Raanan Arens; Patricia Lazalde; James P Choca; Thomas Mosley, Jr; Hector M González

doi:10.1212/WNL.0000000000001181

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Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population

Journal article

Open access

Peer reviewed

Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population

Alberto R Ramos, Wassim Tarraf, Tatjana Rundek, Susan Redline, William K Wohlgemuth, Jose S Loredo, Ralph L Sacco, David J Lee, Raanan Arens, Patricia Lazalde, …

Neurology, Vol.84(4), pp.391-398

2015-01-27

DOI: https://doi.org/10.1212/WNL.0000000000001181

PMCID: PMC4336004

PMID: 25540308

Abstract

United States - ethnology

Humans

Middle Aged

Male

Sleep Apnea, Obstructive - complications

Neuropsychological Tests - statistics & numerical data

Cognition Disorders - etiology

Sleep Apnea, Obstructive - ethnology

Sex Factors

Female

Aged

Hispanic Americans - ethnology

Cognition Disorders - ethnology

We evaluated the association between obstructive sleep apnea (OSA) and neurocognitive function among community-dwelling Hispanic/Latino individuals in the United States. Cross-sectional analysis of the Hispanic Community Health Study/Study of Latinos middle-aged and older adults, aged 45 to 74 years, with neurocognitive test scores at baseline measurements from 2008 to 2011. Neurocognitive scores were measured using the Word Fluency (WF) Test, the Brief-Spanish English Verbal Learning Test (SEVLT), and the Digit Symbol Substitution (DSS) Test. OSA was defined by the apnea-hypopnea index (AHI). Multivariable linear regression models were fit to evaluate relations between OSA and neurocognitive scores. The analysis consisted of 8,059 participants, mean age of 56 years, 55% women, and 41% with less than high school education. The mean AHI was 9.0 (range 0-142; normal AHI <5/h). There was an association between the AHI and all 4 neurocognitive test scores: Brief-SEVLT-sum (β = -0.022) and -recall (β = -0.010), WF (β = -0.023), and DSS (β = -0.050) at p < 0.01 that was fully attenuated by age. In the fully adjusted regression model, female sex was a moderating factor between the AHI and WF (β = -0.027, p < 0.10), SVELT-sum (β = -0.37), SVELT-recall (β = -0.010), and DSS (β = -0.061) at p < 0.01. OSA was associated with worse neurocognitive function in a representative sample of Hispanic/Latino women in the United States.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.137 Sleep Science & Circadian Systems; 1.137.382 Obstructive Sleep Apnea
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior

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Title: Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population
Creators: Alberto R Ramos - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
Wassim Tarraf - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
Tatjana Rundek - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
Susan Redline - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
William K Wohlgemuth - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
Jose S Loredo - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
Ralph L Sacco - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
David J Lee - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
Raanan Arens - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
Patricia Lazalde - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
James P Choca - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
Thomas Mosley, Jr - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing
Hector M González - From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing. hmgonzalez@epi.msu.edu
Publication Details: Neurology, Vol.84(4), pp.391-398
Publisher: United States
Grant note: KL2 TR000461 / NCATS NIH HHS N01-HC65234 / NHLBI NIH HHS N01-HC65233 / NHLBI NIH HHS N01-HC65236 / NHLBI NIH HHS N01-HC65237 / NHLBI NIH HHS N01-HC65235 / NHLBI NIH HHS 1KL2TR000461 / NCATS NIH HHS
Academic Unit: Leadership Department; Miller School of Medicine; UMMG Department of Neurology; UMMG Department of Public Health Sciences Research
Language: English
Resource Type: Journal article
PMID: 25540308
PMCID: PMC4336004
Record Identifier: 991031560641902976