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One-pot three-enzyme synthesis of UDP-GlcNAc derivatives
Journal article

One-pot three-enzyme synthesis of UDP-GlcNAc derivatives

Yi Chen, Vireak Thon, Yanhong Li, Hai Yu, Li Ding, Kam Lau, Jingyao Qu, Liana Hie and Xi Chen
Chemical communications (Cambridge, England), Vol.47(38), pp.10815-10817
2011-10-14
DOI: https://doi.org/10.1039/c1cc14034e
PMID: 21863157

Abstract

Pasteurella multocida - enzymology Bacterial Proteins - metabolism Bifidobacterium - enzymology Inorganic Pyrophosphatase - metabolism Nucleotidyltransferases - metabolism Acetylglucosamine - chemistry Uridine Diphosphate N-Acetylglucosamine - chemical synthesis Acetylglucosamine - chemical synthesis Uridine Diphosphate N-Acetylglucosamine - chemistry
A Pasteurella multocida N-acetylglucosamine 1-phosphate uridylyltransferase (PmGlmU) was cloned and used efficiently with an N-acetylhexosamine 1-kinase (NahK_ATCC55813) and an inorganic pyrophosphatase (PmPpA) for one-pot three-enzyme synthesis of UDP-GlcNAc derivatives with or without further chemical diversification.

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83 Times Cited - Web of Science

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Collaboration types
Domestic collaboration
International collaboration
Citation topics
2 Chemistry
2.1 Synthesis
2.1.522 Thioglycosides
Web Of Science research areas
Chemistry, Multidisciplinary
ESI research areas
Chemistry

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