Operational Development and Launch of an Adaptive Platform Trial in Amyotrophic Lateral Sclerosis: Processes and Learnings From the First Four Regimens of the HEALEY ALS Platform Trial

Brittney A. Harkey; Sofia Distefano; Jaclyn A. Pagliaro; Lindsay Heyd; Marianne Chase; Courtney Igne; Hong Yu; Alexander V. Sherman; Derek Dagostino; Eric Tustison; Genevive Changkuon; Meghan Hall; Gale Kittle; Mariah R. Connolly; Elisa Giacomelli; Erica Scirocco; James D. Berry; Suma Babu; Jeremy Shefner; Eric A. Macklin; Lori B. Chibnik; Annette De Mattos; Kristin Drake; Cornelia Kamp; Andrew McGarry; Margherita Torti; Catherine Small; Allison Bulat; Merit E. Cudkowicz; Sabrina Paganoni; for the HEALEY ALS Platform Trial Study Group; Nathan Carberry; Michael Benatar

doi:10.1002/mus.28442

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Operational Development and Launch of an Adaptive Platform Trial in Amyotrophic Lateral Sclerosis: Processes and Learnings From the First Four Regimens of the HEALEY ALS Platform Trial

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Operational Development and Launch of an Adaptive Platform Trial in Amyotrophic Lateral Sclerosis: Processes and Learnings From the First Four Regimens of the HEALEY ALS Platform Trial

Brittney A. Harkey, Sofia Distefano, Jaclyn A. Pagliaro, Lindsay Heyd, Marianne Chase, Courtney Igne, Hong Yu, Alexander V. Sherman, Derek Dagostino, Eric Tustison, …

Muscle & nerve, Vol.72(2), pp.294-305

2025-08

DOI: https://doi.org/10.1002/mus.28442

PMID: 40420561

Appears in Miller School of Medicine - Latest Publications

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Title: Operational Development and Launch of an Adaptive Platform Trial in Amyotrophic Lateral Sclerosis: Processes and Learnings From the First Four Regimens of the HEALEY ALS Platform Trial
Creators: Brittney A. Harkey - Clinical Research Institute
Sofia Distefano - Clinical Research Institute
Jaclyn A. Pagliaro - Clinical Research Institute
Lindsay Heyd - Clinical Research Institute
Marianne Chase - Clinical Research Institute
Courtney Igne - Clinical Research Institute
Hong Yu - Clinical Research Institute
Alexander V. Sherman - Clinical Research Institute
Derek Dagostino - Harvard Medical School
Eric Tustison - Clinical Research Institute
Genevive Changkuon - Clinical Research Institute
Meghan Hall - Barrow Neurological Institute
Gale Kittle - Barrow Neurological Institute
Mariah R. Connolly - Barrow Neurological Institute
Elisa Giacomelli - Clinical Research Institute
Erica Scirocco - Clinical Research Institute
James D. Berry - Clinical Research Institute
Suma Babu - Clinical Research Institute
Jeremy Shefner - Barrow Neurological Institute
Eric A. Macklin - Massachusetts General Hospital
Lori B. Chibnik - Massachusetts General Hospital
Annette De Mattos - Clinical Research Institute
Kristin Drake - Clinical Research Institute
Cornelia Kamp - University of Rochester
Andrew McGarry - Clintrex Research Corporation Sarasota Florida USA
Margherita Torti - Clintrex Research Corporation Sarasota Florida USA
Catherine Small - Clinical Research Institute
Allison Bulat - Clinical Research Institute
Merit E. Cudkowicz - Clinical Research Institute
Sabrina Paganoni - Clinical Research Institute
for the HEALEY ALS Platform Trial Study Group
Nathan Carberry - UMMG Department of Neurology
Michael Benatar - UMMG Department of Neurology
Publication Details: Muscle & nerve, Vol.72(2), pp.294-305
Number of pages: 12
Academic Unit: Miller School of Medicine; UMMG Department of Neurology; UMMG Dept of Neurology - Neuromuscular Disorders Div
Language: English
Resource Type: Journal article
PMID: 40420561
Record Identifier: 991032796291602976