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Organizational differences in the membrane proteins of normal and irreversibly sickled erythrocytes
Journal article   Peer reviewed

Organizational differences in the membrane proteins of normal and irreversibly sickled erythrocytes

Robert W Rubin, Clara Milikowski and Gary E Wise
Biochimica et biophysica acta. Biomembranes, Vol.595(1), pp.1-8
1980
DOI: https://doi.org/10.1016/0005-2736(80)90241-2

Abstract

Ion flux Potential change Capping Lymphocyte Fluorescent probe
Using two-dimensional gels, no unique membrane proteins were detected in irreversibly sickled cells. Membranes from irreversibly sickled cells were shown to cross-link much more readily with dithiobis(succinimidyl propionate) than normal erythrocyte membranes. Increased binding of band 4.5 protein and increased intra-chain disulfides were also demonstrated. These changes may correlate to enhanced cellular rigidity.

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12 Times Cited - Web of Science

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Citation topics
1 Clinical & Life Sciences
1.225 Hematologic Diseases
1.225.786 Spectrin
Web Of Science research areas
Biochemistry & Molecular Biology
Biophysics
ESI research areas
Biology & Biochemistry

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#3 Good Health and Well-Being

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