PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature

Jian Xiao; Cheng-Ping Hu; Bi-Xiu He; Xi Chen; Xiao-Xiao Lu; Ming-Xuan Xie; Wei Li; Shu-Ya He; Shao-Jin You; Qiong Chen

doi:10.18632/oncotarget.11068

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PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature

Journal article

Open access

Peer reviewed

PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature

Jian Xiao, Cheng-Ping Hu, Bi-Xiu He, Xi Chen, Xiao-Xiao Lu, Ming-Xuan Xie, Wei Li, Shu-Ya He, Shao-Jin You and Qiong Chen

Oncotarget, Vol.7(36), pp.57832-57840

2016-09-06

DOI: https://doi.org/10.18632/oncotarget.11068

PMCID: PMC5295393

PMID: 27506936

Abstract

Lung Neoplasms - genetics

Multivariate Analysis

PTEN Phosphohydrolase - genetics

Prognosis

Biomarkers, Tumor - analysis

Carcinoma, Non-Small-Cell Lung - genetics

Humans

Lung Neoplasms - metabolism

Carcinoma, Non-Small-Cell Lung - metabolism

PTEN Phosphohydrolase - metabolism

Treatment Outcome

Carcinoma, Non-Small-Cell Lung - diagnosis

Disease-Free Survival

Lung Neoplasms - diagnosis

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a known tumor suppressor in non-small cell lung cancer (NSCLC). By performing a systematic review and meta-analysis of the literature, we determined the prognostic value of decreased PTEN expression in patients with NSCLC. We comprehensively and systematically searched through multiple online databases up to May 22, 2016 for NSCLC studies reporting on PTEN expression and patient survival outcome. Several criteria, including the Newcastle-Ottawa Quality Assessment Scale (NOS), were used to discriminate between studies. In total, 23 eligible studies with a total of 2,505 NSCLC patients were included in our meta-analysis. Our results demonstrated that decreased expression of PTEN correlated with poor overall survival in NSCLC patients and was indicative of a poor prognosis for disease-free survival and progression-free survival in patients with NSCLC.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis; 1.25.803 mTOR
Web Of Science research areas: Cell Biology; Oncology
ESI research areas: Molecular Biology & Genetics

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Title: PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature
Creators: Jian Xiao - Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China
Cheng-Ping Hu - Department of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China
Bi-Xiu He - Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China
Xi Chen - Department of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China
Xiao-Xiao Lu - Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China
Ming-Xuan Xie - Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China
Wei Li - Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China
Shu-Ya He - Department of Biochemistry and Biology, University of South China, Hengyang 421001, China
Shao-Jin You - Laboratory of Cancer Experimental Therapy, Atlanta Research and Educational Foundation (151F), Atlanta VA Medical Center, Decatur, GA 30033, USA
Qiong Chen - Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha 410008, China
Publication Details: Oncotarget, Vol.7(36), pp.57832-57840
Academic Unit: Miller School of Medicine; UMMG Department of Public Health Sciences Research
Language: English
Resource Type: Journal article
PMID: 27506936
PMCID: PMC5295393
Record Identifier: 991031599754802976