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PTPRC ( CD45 ) is not associated with the development of multiple sclerosis in U.S. patients
Journal article   Peer reviewed

PTPRC ( CD45 ) is not associated with the development of multiple sclerosis in U.S. patients

Leonard Dragone, Stacy Caillier, Robin R Lincoln, Melissa Elder, Margaret Pericak-Vance, Jonathan L Haines, Jorge R Oksenberg, Arthur Weiss, Lisa F Barcellos, Eric Vittinghoff, …
Nature genetics, Vol.29(1), pp.23-24
2001-09
PMID: 11528386

Abstract

A C→G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS). We performed an extensive evaluation of this polymorphism using large family-based and case-control comparisons. Overall, we observed no evidence of genetic association between the PTPRC polymorphism and MS susceptibility or disease course.

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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.6 Immunology
1.6.127 T Cell Receptor
Web Of Science research areas
Genetics & Heredity
ESI research areas
Molecular Biology & Genetics

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#3 Good Health and Well-Being

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