Paclitaxel Modulates TGFβ Signaling in Scleroderma Skin Grafts in Immunodeficient Mice

Xialin Liu; Shoukang Zhu; Tao Wang; Laura Hummers; Fredrick M Wigley; Pascal J Goldschmidt-Clermont; Chunming Dong

doi:10.1371/journal.pmed.0020354

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Paclitaxel Modulates TGFβ Signaling in Scleroderma Skin Grafts in Immunodeficient Mice

Journal article

Open access

Paclitaxel Modulates TGFβ Signaling in Scleroderma Skin Grafts in Immunodeficient Mice

Xialin Liu, Shoukang Zhu, Tao Wang, Laura Hummers, Fredrick M Wigley, Pascal J Goldschmidt-Clermont and Chunming Dong

PLoS medicine, Vol.2(12), pp.1334-1342

2005-12

DOI: https://doi.org/10.1371/journal.pmed.0020354

PMID: 16250671

Appears in UM Open Access Research Published in PloS

Abstract

Connective Tissue Disease

Dermatology

Immunology and Allergy

Rheumatology

In a mouse model of Systemic sclerosis low-dose paclitaxel can suppress an important disease-related pathway, that involves TGFβ and Smad, and lessen fibrosis .

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.106 Rheumatology; 1.106.1083 Systemic Sclerosis
Web Of Science research areas: Rheumatology
ESI research areas: Clinical Medicine

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Details

Title: Paclitaxel Modulates TGFβ Signaling in Scleroderma Skin Grafts in Immunodeficient Mice
Creators: Xialin Liu - Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Shoukang Zhu - Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Tao Wang - Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Laura Hummers - Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland, United States of America
Fredrick M Wigley - Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland, United States of America
Pascal J Goldschmidt-Clermont - Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Chunming Dong - Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Publication Details: PLoS medicine, Vol.2(12), pp.1334-1342
Publisher: Public Library of Science; San Francisco, USA
Academic Unit: Miller School of Medicine
Language: English
Resource Type: Journal article
PMID: 16250671
Record Identifier: 991031560311202976