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Post-translational modifications of Runx1 regulate its activity in the cell
Journal article   Open access  Peer reviewed

Post-translational modifications of Runx1 regulate its activity in the cell

Lan Wang, Gang Huang, Xinyang Zhao, Megan A Hatlen, Ly Vu, Fan Liu and Stephen D Nimer
Blood cells, molecules, & diseases, Vol.43(1), pp.30-34
2009
DOI: https://doi.org/10.1016/j.bcmd.2009.03.005
PMCID: PMC2743917
PMID: 19386523

Abstract

Acetylation Methyltransferases Transcription Methylation Leukemia Acetyltransferases
In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1–ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.
url
https://doi.org/10.1016/j.bcmd.2009.03.005View
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Citation topics
1 Clinical & Life Sciences
1.103 Blood Disorders
1.103.155 Acute Myeloid Leukemia
Web Of Science research areas
Hematology
ESI research areas
Clinical Medicine

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