Potent Inhibitors of Huntingtin Protein Aggregation in a Cell-Based Assay

Alison Rinderspacher; Maria Laura Cremona; Yidong Liu; Shi-Xian Deng; Yuli Xie; Gangli Gong; Nathalie Aulner; Udo Többen; Katherine Myers; Caty Chung; Monique Andersen; Dušica Vidović; Stephan Schürer; Lars Brandén; Ai Yamamoto; Donald W Landry

doi:10.1016/j.bmcl.2009.01.087

Back

Potent Inhibitors of Huntingtin Protein Aggregation in a Cell-Based Assay

Journal article

Open access

Peer reviewed

Potent Inhibitors of Huntingtin Protein Aggregation in a Cell-Based Assay

Alison Rinderspacher, Maria Laura Cremona, Yidong Liu, Shi-Xian Deng, Yuli Xie, Gangli Gong, Nathalie Aulner, Udo Többen, Katherine Myers, Caty Chung, …

Bioorganic & medicinal chemistry letters, Vol.19(6), pp.1715-1717

2009-03-15

DOI: https://doi.org/10.1016/j.bmcl.2009.01.087

PMCID: PMC2710884

PMID: 19243939

Abstract

A quinazoline that decreases polyglutamine aggregate burden in a cell-based assay was identified from a high-throughput screen of a chemical-compound library, provided by the NIH Molecular Libraries Small Molecule Repository (MLSMR). A structure and activity study yielded leads with submicromolar potency.

Files and links (1)

url

https://doi.org/10.1016/j.bmcl.2009.01.087View

Published (Version of record) Open

Metrics

27 Record Views

8 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.951 Huntington's Disease
Web Of Science research areas: Chemistry, Medicinal; Chemistry, Organic
ESI research areas: Chemistry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Potent Inhibitors of Huntingtin Protein Aggregation in a Cell-Based Assay
Creators: Alison Rinderspacher - Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Maria Laura Cremona - Genome Center, Columbia University, 1150 St. Nicholas Ave., New York, NY 10032, USA
Yidong Liu - Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Shi-Xian Deng - Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Yuli Xie - Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Gangli Gong - Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Nathalie Aulner - Genome Center, Columbia University, 1150 St. Nicholas Ave., New York, NY 10032, USA
Udo Többen - Genome Center, Columbia University, 1150 St. Nicholas Ave., New York, NY 10032, USA
Katherine Myers - Genome Center, Columbia University, 1150 St. Nicholas Ave., New York, NY 10032, USA
Caty Chung - Scientific Computing, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, FL 33458 USA
Monique Andersen - Department of Neurology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Dušica Vidović - Scientific Computing, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, FL 33458 USA
Stephan Schürer - Scientific Computing, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, FL 33458 USA
Lars Brandén - Genome Center, Columbia University, 1150 St. Nicholas Ave., New York, NY 10032, USA
Ai Yamamoto - Department of Neurology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Donald W Landry - Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Publication Details: Bioorganic & medicinal chemistry letters, Vol.19(6), pp.1715-1717
Academic Unit: Miller School of Medicine; Molecular and Cellular Pharmacology Research
Language: English
Resource Type: Journal article
PMID: 19243939
PMCID: PMC2710884
Record Identifier: 991031560998302976