Abstract
A series of oxime ethers
1 and
2 have been synthesized and evaluated for their hypotensive activity.
The synthesis and pharmacological evaluation of substituted oximino-ethers
1 and
2 of naphth[1,2-
b]- and naphth[2,1-
b]-oxepin-5-ones (
4 and
8) were carried out. The hypotensive activity of oximino-ethers
1 and
2 was evaluated on anaesthetized cats. The results indicated that
1c caused a fall of 80
mm/Hg for >100′ at a dose of 5
mg/kg iv in anaesthetized cats.
