Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey

Samson W Fine; Kiril Trpkov; Mahul B Amin; Ferran Algaba; Manju Aron; Dilek E Baydar; Antonio Lopez Beltran; Fadi Brimo; John C Cheville; Maurizio Colecchia; Eva Comperat; Tony Costello; Isabela Werneck da Cunha; Warick Delprado; Angelo M DeMarzo; Giovanna A Giannico; Jennifer B Gordetsky; Charles C Guo; Donna E Hansel; Michelle S Hirsch; Jiaoti Huang; Peter A Humphrey; Rafael E Jimenez; Francesca Khani; Max X Kong; Oleksandr N Kryvenko; L. Priya Kunju; Priti Lal; Mathieu Latour; Tamara Lotan; Fiona Maclean; Cristina Magi-Galluzzi; Rohit Mehra; Santosh Menon; Hiroshi Miyamoto; Rodolfo Montironi; George J Netto; Jane K Nguyen; Adeboye O Osunkoya; Anil Parwani; Christian P Pavlovich; Brian D Robinson; Mark A Rubin; Rajal B Shah; Jeffrey S So; Hiroyuki Takahashi; Fabio Tavora; Maria S Tretiakova; Lawrence True; Sara E Wobker; Ximing J Yang; Ming Zhou; Debra L Zynger; Jonathan I Epstein

doi:10.1016/j.urolonc.2020.08.027

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Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey

Journal article

Peer reviewed

Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey

Samson W Fine, Kiril Trpkov, Mahul B Amin, Ferran Algaba, Manju Aron, Dilek E Baydar, Antonio Lopez Beltran, Fadi Brimo, John C Cheville, Maurizio Colecchia, …

Urologic oncology, Vol.39(5), pp.295.e1-295.e8

2021-05

DOI: https://doi.org/10.1016/j.urolonc.2020.08.027

PMID: 32948433

Abstract

Active surveillance

Cribriform

Grading

MRI

Prostate cancer

•GUPS survey: 834 clinician responses on practice patterns related to prostate cancer grading.•Includes % high-grade disease, cribriform/intraductal carcinoma, and MRI-targeted biopsy.•Highlights similarities/differences between pathology reporting and clinical application. To survey urologic clinicians regarding interpretation of and practice patterns in relation to emerging aspects of prostate cancer grading, including quantification of high-grade disease, cribriform/intraductal carcinoma, and impact of magnetic resonance imaging-targeted needle biopsy. The Genitourinary Pathology Society distributed a survey to urology and urologic oncology-focused societies and hospital departments. Eight hundred and thirty four responses were collected and analyzed using descriptive statistics. Eighty percent of survey participants use quantity of Gleason pattern 4 on needle biopsy for clinical decisions, less frequently with higher Grade Groups. Fifty percent interpret “tertiary” grade as a minor/<5% component. Seventy percent of respondents would prefer per core grading as well as a global/overall score per set of biopsies, but 70% would consider highest Gleason score in any single core as the grade for management. Seventy five percent utilize Grade Group terminology in patient discussions. For 45%, cribriform pattern would affect management, while for 70% the presence of intraductal carcinoma would preclude active surveillance. This survey of practice patterns in relationship to prostate cancer grading highlights similarities and differences between contemporary pathology reporting and its clinical application. As utilization of Gleason pattern 4 quantification, minor tertiary pattern, cribriform/intraductal carcinoma, and the incorporation of magnetic resonance imaging-based strategies evolve, these findings may serve as a basis for more nuanced communication and guide research efforts involving pathologists and clinicians.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.147 Prostate Cancer; 1.147.97 Prostate Cancer
Web Of Science research areas: Oncology; Urology & Nephrology
ESI research areas: Clinical Medicine

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Details

Title: Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey
Creators: Samson W Fine - Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
Kiril Trpkov - Department of Pathology and Lab Medicine, University of Calgary and Alberta Precision Labs, Calgary, AB, Canada
Mahul B Amin - Department of Pathology and Laboratory Medicine and Urology, University of Tennessee Health Science, Memphis, TN
Ferran Algaba - Department of Pathology, Fundacio Puigvert, Barcelona, Spain
Manju Aron - Department of Pathology, University of Southern California, Los Angeles, CA
Dilek E Baydar - Department of Pathology, Faculty of Medicine, Koç University, İstanbul, Turkey
Antonio Lopez Beltran - Department of Pathology, Champalimaud Centre for the Unknown, Lisbon, Portugal
Fadi Brimo - Department of Pathology, McGill University Health Center, Montréal, QC, Canada
John C Cheville - Department of Pathology, Mayo Clinic, Rochester, MN
Maurizio Colecchia - Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Eva Comperat - Department of Pathology, Hôpital Tenon, Sorbonne University, Paris, France
Tony Costello - Department of Urology, Royal Melbourne Hospital, Melbourne, Australia
Isabela Werneck da Cunha - Pathology Department, Rede D'OR-Sao Luiz; Sao Paulo, SP, Brazil
Warick Delprado - Douglass Hanly Moir Pathology, Sydney, Australia
Angelo M DeMarzo - Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD
Giovanna A Giannico - Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN
Jennifer B Gordetsky - Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN
Charles C Guo - Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
Donna E Hansel - Department of Pathology, Oregon Health and Science University Portland OR, USA
Michelle S Hirsch - Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Jiaoti Huang - Department of Pathology, Duke University School of Medicine, Durham, NC
Peter A Humphrey - Department of Pathology, Yale School of Medicine, New Haven, CT
Rafael E Jimenez - Department of Pathology, Mayo Clinic, Rochester, MN
Francesca Khani - Department of Pathology and Laboratory Medicine and Urology, Weill Cornell Medicine, New York, NY
Max X Kong - Department of Pathology, Kaiser Permanente Sacramento Medical Center, CA
Oleksandr N Kryvenko - Departments of Pathology and Laboratory Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL
L. Priya Kunju - Department of Pathology, University of Michigan Medical School, Ann Arbor, MI
Priti Lal - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Mathieu Latour - Department of Pathology, CHUM, Université de Montréal, Montréal, QC, Canada
Tamara Lotan - Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD
Fiona Maclean - Douglass Hanly Moir Pathology, Sydney, Australia
Cristina Magi-Galluzzi - Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL
Rohit Mehra - Department of Pathology, University of Michigan Medical School, Ann Arbor, MI
Santosh Menon - Department of Surgical Pathology, Tata Memorial Hospital, Parel, Mumbai, India
Hiroshi Miyamoto - Departments of Pathology and Laboratory Medicine and Urology, University of Rochester Medical Center, Rochester, NY
Rodolfo Montironi - Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region, United Hospitals, Ancona, Italy
George J Netto - Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL
Jane K Nguyen - Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH
Adeboye O Osunkoya - Department of Pathology, Emory University School of Medicine, Atlanta, GA
Anil Parwani - Department of Pathology, Ohio State University, Columbus, OH
Christian P Pavlovich - Departments of Urology and Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD
Brian D Robinson - Department of Pathology and Laboratory Medicine and Urology, Weill Cornell Medicine, New York, NY
Mark A Rubin - Department for BioMedical Research, University of Bern, Bern, Switzerland
Rajal B Shah - Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX
Jeffrey S So - Institute of Pathology, St Luke's Medical Center, Quezon City and Global City, Philippines
Hiroyuki Takahashi - Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan
Fabio Tavora - Argos Laboratory, Federal University of Ceara, Fortaleza, Brazil
Maria S Tretiakova - Department of Pathology, University of Washington School of Medicine, Seattle, WA
Lawrence True - Department of Pathology, University of Washington School of Medicine, Seattle, WA
Sara E Wobker - Departments of Pathology and Laboratory Medicine and Urology, University of North Carolina, Chapel Hill, NC
Ximing J Yang - Department of Pathology, Northwestern University, Chicago, IL
Ming Zhou - Department of Pathology, Tufts Medical Center, Boston, MA
Debra L Zynger - Department of Pathology, Ohio State University, Columbus, OH
Jonathan I Epstein - Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD
Publication Details: Urologic oncology, Vol.39(5), pp.295.e1-295.e8
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 32948433
Record Identifier: 991031599270602976