Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

Matthias W Lorenz; Lu Gao; Kathrin Ziegelbauer; Giuseppe Danilo Norata; Jean Philippe Empana; Irene Schmidtmann; Hung-Ju Lin; Stela McLachlan; Lena Bokemark; Kimmo Ronkainen; Mauro Amato; Ulf Schminke; Sathanur R Srinivasan; Lars Lind; Shuhei Okazaki; Coen D A Stehouwer; Peter Willeit; Joseph F Polak; Helmuth Steinmetz; Dirk Sander; Holger Poppert; Moise Desvarieux; M Arfan Ikram; Stein Harald Johnsen; Daniel Staub; Cesare R Sirtori; Bernhard Iglseder; Oscar Beloqui; Gunnar Engström; Alfonso Friera; Francesco Rozza; Wuxiang Xie; Grace Parraga; Liliana Grigore; Matthieu Plichart; Stefan Blankenberg; Ta-Chen Su; Caroline Schmidt; Tomi-Pekka Tuomainen; Fabrizio Veglia; Henry Völzke; Giel Nijpels; Johann Willeit; Ralph L Sacco; Oscar H Franco; Heiko Uthoff; Bo Hedblad; Carmen Suarez; Raffaele Izzo; Dong Zhao; Thapat Wannarong; Alberico Catapano; Pierre Ducimetiere; Christine Espinola-Klein; Kuo-Liong Chien; Jackie F Price; Göran Bergström; Jussi Kauhanen; Elena Tremoli; Marcus Dörr; Gerald Berenson; Kazuo Kitagawa; Jacqueline M Dekker; Stefan Kiechl; Matthias Sitzer; Horst Bickel; Tatjana Rundek; Albert Hofman; Ellisiv B Mathiesen; Samuela Castelnuovo; Manuel F Landecho; Maria Rosvall; Rafael Gabriel; Nicola de Luca; Jing Liu; Damiano Baldassarre; Maryam Kavousi; Eric de Groot; Michiel L Bots; David N Yanez; Simon G Thompson

doi:10.1371/journal.pone.0191172

Back

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

Journal article

Open access

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

Matthias W Lorenz, Lu Gao, Kathrin Ziegelbauer, Giuseppe Danilo Norata, Jean Philippe Empana, Irene Schmidtmann, Hung-Ju Lin, Stela McLachlan, Lena Bokemark, Kimmo Ronkainen, …

PloS one, Vol.13(4), pp.e0191172-e0191172

2018

DOI: https://doi.org/10.1371/journal.pone.0191172

PMCID: PMC5896895

PMID: 29649236

Appears in UM Open Access Research Published in PloS

Abstract

Prognosis

Carotid Intima-Media Thickness

Humans

Intersectoral Collaboration

Middle Aged

Risk Factors

Cardiovascular Diseases - diagnostic imaging

Cardiovascular Diseases - epidemiology

Female

Male

Aged

Cardiovascular Diseases - diagnosis

Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Files and links (1)

url

https://doi.org/10.1371/journal.pone.0191172View

Published (Version of record) Open

Metrics

6 Record Views

50 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.105 Strokes; 1.105.429 Carotid Endarterectomy
Web Of Science research areas: Peripheral Vascular Disease
ESI research areas: Clinical Medicine

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration
Creators: Matthias W Lorenz - Department of Neurology, Goethe University, Frankfurt am Main, Germany
Lu Gao - MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, United Kingdom
Kathrin Ziegelbauer - Department of Neurology, Goethe University, Frankfurt am Main, Germany
Giuseppe Danilo Norata - SISA Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Italy
Jean Philippe Empana - Paris Cardiovascular Research Centre (PARCC), University Paris Descartes, Sorbonne Paris Cité, UMR, Paris, France
Irene Schmidtmann - Institut fuer Medizinische Biometrie, Epidemiologie und Informatik (IMBEI), Universitaetsmedizin Mainz, Mainz, Germany
Hung-Ju Lin - Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Stela McLachlan - Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom
Lena Bokemark - Wallenberg Laboratory for Cardiovascular Research, Institution for Medicin, Department for Molecular and Clinical Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
Kimmo Ronkainen - Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
Mauro Amato - Centro Cardiologico Monzino, IRCCS, Milano, Italy
Ulf Schminke - Department of Neurology, Greifswald University Clinic, Greifswald, Germany
Sathanur R Srinivasan - Center for Cardiovascular Health, Department of Epidemiology, Biochemistry, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America
Lars Lind - Department of Medicine, Uppsala University, Uppsala, Sweden
Shuhei Okazaki - Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan
Coen D A Stehouwer - Department of Internal Medicine and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, the Netherlands
Peter Willeit - Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
Joseph F Polak - Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America
Helmuth Steinmetz - Department of Neurology, Goethe University, Frankfurt am Main, Germany
Dirk Sander - Department of Neurology, Benedictus Hospital Tutzing & Feldafing, Feldafing, Germany
Holger Poppert - Department of Neurology, Technische Universität München, Munich, Germany
Moise Desvarieux - Department of Epidemiology,Mailman School of Public Health,Columbia University, New York, United States of America
M Arfan Ikram - Department of Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands
Stein Harald Johnsen - Department of Neurology, University Hospital of Northern Norway, Tromsø, Norway
Daniel Staub - Department of Angiology, University Hospital Basel, Basel, Switzerland
Cesare R Sirtori - Center of Dyslipidemias, Niguarda Ca' Granda Hospital, Milano, Italy
Bernhard Iglseder - Department of Geriatric Medicine, Gemeinnützige Salzburger Landeskliniken Betriebsgesellschaft GmbH Christian-Doppler-Klinik, Salzburg, Austria
Oscar Beloqui - Department of Internal Medicine, University Clinic of Navarra, Navarra, Spain
Gunnar Engström - Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
Alfonso Friera - Radiology Department, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain
Francesco Rozza - School of Medicine, Federico II University, Naples, Italy
Wuxiang Xie - Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Grace Parraga - Robarts Research Institute, Western University, London, Ontario, Canada
Liliana Grigore - Centro Sisa per lo Studio della Aterosclerosi, Bassini Hospital, Cinisello Balsamo, Italy
Matthieu Plichart - Assistance Publique, Hôpitaux de Paris, Hôpital Broca, Paris, France
Stefan Blankenberg - Department of Cardiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Ta-Chen Su - Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
Caroline Schmidt - Wallenberg Laboratory for Cardiovascular Research, University of Gothenburg, Gothenburg, Sweden
Tomi-Pekka Tuomainen - Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
Fabrizio Veglia - Centro Cardiologico Monzino, IRCCS, Milano, Italy
Henry Völzke - Institute for Community Medicine, SHIP/Clinical-Epidemiological Research, Greifswald, Germany
Giel Nijpels - EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands
Johann Willeit - Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
Ralph L Sacco - Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
Oscar H Franco - Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
Heiko Uthoff - Department of Angiology, University Hospital Basel, Basel, Switzerland
Bo Hedblad - Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
Carmen Suarez - Internal Medicine Department, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain
Raffaele Izzo - School of Medicine, Federico II University, Naples, Italy
Dong Zhao - Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Thapat Wannarong - Department of Internal Medicine, Faculty of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Alberico Catapano - Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
Pierre Ducimetiere - University Paris_Sud Xi, Kremlin-Bicêtre, Le Kremlin-Bicêtre, France
Christine Espinola-Klein - 2nd Department of Medicine, Johannes-Gutenberg University, Mainz, Germany
Kuo-Liong Chien - Institute of Epidemiology and Preventive Medicine, College of Public Health,National Taiwan University, Taipei, Taiwan
Jackie F Price - Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom
Göran Bergström - Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Gothenburg University, Götheborg, Sweden
Jussi Kauhanen - Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
Elena Tremoli - Centro Cardiologico Monzino, IRCCS, Milano, Italy
Marcus Dörr - Department B for Internal Medicine, University Medicine Greifswald, Greifswald, Germany
Gerald Berenson - Department of Medicine, Pediatrics, Biochemistry, Epidemiology, Tulane University School of Medicine and School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America
Kazuo Kitagawa - Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan
Jacqueline M Dekker - Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands
Stefan Kiechl - Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
Matthias Sitzer - Department of Neuology, Klinikum Herford, Herford, Germany
Horst Bickel - Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany
Tatjana Rundek - Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
Albert Hofman - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
Ellisiv B Mathiesen - Department of Clinical Medicine, Uit The Arctic University of Norway, Tromsø, Norway
Samuela Castelnuovo - Center of Dyslipidemias, Niguarda Ca' Granda Hospital, Milano, Italy
Manuel F Landecho - Department of Internal Medicine, University Clinic of Navarra, Navarra, Spain
Maria Rosvall - Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
Rafael Gabriel - Escuela National de Sanidad, Instituto de Salud Carlos III, Madrid, Spain
Nicola de Luca - School of Medicine, Federico II University, Naples, Italy
Jing Liu - Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Damiano Baldassarre - Centro Cardiologico Monzino, IRCCS, Milano, Italy
Maryam Kavousi - Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands
Eric de Groot - Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, Amsterdam, the Netherlands
Michiel L Bots - Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
David N Yanez - Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
Simon G Thompson - Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
Publication Details: PloS one, Vol.13(4), pp.e0191172-e0191172
Publisher: United States
Grant note: HHSN268201200036C / NHLBI NIH HHS R01 AG027058 / NIA NIH HHS N01HC55222 / NHLBI NIH HHS N01HC85086 / NHLBI NIH HHS K24 NS062737 / NINDS NIH HHS R56 AG020098 / NIA NIH HHS R01 AG015928 / NIA NIH HHS U01 HL080295 / NHLBI NIH HHS N01HC75150 / NHLBI NIH HHS R01 DE013094 / NIDCR NIH HHS RG/13/13/30194 / British Heart Foundation MR/L003120/1 / Medical Research Council R01 AG020098 / NIA NIH HHS R37 NS029993 / NINDS NIH HHS N01 HC015103 / NHLBI NIH HHS R01 AG023629 / NIA NIH HHS N01 HC035129 / NHLBI NIH HHS R56 AG023629 / NIA NIH HHS N01 HC045133 / NHLBI NIH HHS N01HC85079 / NHLBI NIH HHS R01 HL080295 / NHLBI NIH HHS
Academic Unit: Leadership Department; Miller School of Medicine; UMMG Department of Neurology
Language: English
Resource Type: Journal article
PMID: 29649236
PMCID: PMC5896895
Record Identifier: 991031577654402976