Premature B-cell senescence as a consequence of chronic immune activation: Implications for vaccination of immune compromised individuals

Paolo Palma; Stefano Rinaldi; Nicola Cotugno; Veronica Santilli; Savita Pahwa; Paolo Rossi; Alberto Cagigi

doi:10.4161/hv.28698

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Premature B-cell senescence as a consequence of chronic immune activation: Implications for vaccination of immune compromised individuals

Journal article

Peer reviewed

Premature B-cell senescence as a consequence of chronic immune activation: Implications for vaccination of immune compromised individuals

Paolo Palma, Stefano Rinaldi, Nicola Cotugno, Veronica Santilli, Savita Pahwa, Paolo Rossi and Alberto Cagigi

Human vaccines & immunotherapeutics, Vol.10(7), pp.2083-2088

2014-07-01

DOI: https://doi.org/10.4161/hv.28698

PMID: 25424820

Abstract

predictive biomarkers

immunosenescence

inflammaging

mature-activated B-cells

immunization

Review

aging

double negative B-cells

activation-induced deaminase (AID)

Similar features between the immune system of healthy elderly people and of younger individuals subjected to conditions of chronic immune activation are progressively being observed. This is raising the hypothesis that chronic immune activation may cause the premature aging of the immune system. Here we dissect this theory by comparing changes occurring to B-cells during healthy aging to the ones occurring during chronic immune activation in younger individuals. Moreover, we discuss how these changes may affect or predict response to vaccination in immune compromised individuals.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.452 Somatic Hypermutation
Web Of Science research areas: Biotechnology & Applied Microbiology; Immunology
ESI research areas: Immunology

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Details

Title: Premature B-cell senescence as a consequence of chronic immune activation
Creators: Paolo Palma - University Department of Pediatrics; DPUO; Unit of Immune and Infectious Diseases; Bambino Gesù Children’s Hospital; Rome, Italy
Stefano Rinaldi - Chair of Pediatrics; Department of Public Health; University of Rome
Nicola Cotugno - University Department of Pediatrics; DPUO; Unit of Immune and Infectious Diseases; Bambino Gesù Children’s Hospital; Rome, Italy
Veronica Santilli - University Department of Pediatrics; DPUO; Unit of Immune and Infectious Diseases; Bambino Gesù Children’s Hospital; Rome, Italy
Savita Pahwa - Department of Microbiology and Immunology; University of Miami; Miller School of Medicine; Miami, FL USA
Paolo Rossi - University Department of Pediatrics; DPUO; Unit of Immune and Infectious Diseases; Bambino Gesù Children’s Hospital; Rome, Italy
Alberto Cagigi - University Department of Pediatrics; DPUO; Unit of Immune and Infectious Diseases; Bambino Gesù Children’s Hospital; Rome, Italy
Publication Details: Human vaccines & immunotherapeutics, Vol.10(7), pp.2083-2088
Publisher: Landes Bioscience
Academic Unit: Miller School of Medicine; Microbiology and Immunology Research
Language: English
Resource Type: Journal article
PMID: 25424820
Record Identifier: 991031562556902976