Prophylactic Antiepileptic Drug Use and Outcome in the Ethnic/Racial Variations of Intracerebral Hemorrhage Study

Kevin N Sheth; Sharyl R Martini; Charles J Moomaw; Sebastian Koch; Mitchell S V Elkind; Gene Sung; Steven J Kittner; Michael Frankel; Jonathan Rosand; Carl D Langefeld; Mary E Comeau; Salina P Waddy; Jennifer Osborne; Daniel Woo

doi:10.1161/STROKEAHA.115.010875

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Prophylactic Antiepileptic Drug Use and Outcome in the Ethnic/Racial Variations of Intracerebral Hemorrhage Study

Journal article

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Peer reviewed

Prophylactic Antiepileptic Drug Use and Outcome in the Ethnic/Racial Variations of Intracerebral Hemorrhage Study

Kevin N Sheth, Sharyl R Martini, Charles J Moomaw, Sebastian Koch, Mitchell S V Elkind, Gene Sung, Steven J Kittner, Michael Frankel, Jonathan Rosand, Carl D Langefeld, …

Stroke (1970), Vol.46(12), pp.3532-3535

2015-12

DOI: https://doi.org/10.1161/STROKEAHA.115.010875

PMCID: PMC4659755

PMID: 26470777

Abstract

Cerebral Hemorrhage - drug therapy

Prospective Studies

Cerebral Hemorrhage - ethnology

Ethnic Groups - ethnology

Continental Population Groups - ethnology

Humans

Middle Aged

Risk Factors

Post-Exposure Prophylaxis - methods

Anticonvulsants - administration & dosage

Male

Treatment Outcome

Cerebral Hemorrhage - diagnosis

Female

Aged

Cohort Studies

The role of antiepileptic drug (AED) prophylaxis after intracerebral hemorrhage (ICH) remains unclear. This analysis describes prevalence of prophylactic AED use, as directed by treating clinicians, in a prospective ICH cohort and tests the hypothesis that it is associated with poor outcome. Analysis included 744 patients with ICH enrolled in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study before November 2012. Baseline clinical characteristics and AED use were recorded in standardized fashion. ICH location and volume were recorded from baseline neuroimaging. We analyzed differences in patient characteristics by AED prophylaxis, and we used logistic regression to test whether AED prophylaxis was associated with poor outcome. The primary outcome was 3-month modified Rankin Scale score, with 4 to 6 considered poor outcome. AEDs were used for prophylaxis in 289 (39%) of the 744 subjects; of these, levetiracetam was used in 89%. Patients with lobar ICH, craniotomy, or larger hematomas were more likely to receive prophlyaxis. Although prophylactic AED use was associated with poor outcome in an unadjusted model (odds ratio, 1.40; 95% confidence interval, 1.04-1.88; P=0.03), this association was no longer significant after adjusting for clinical and demographic characteristics (odds ratio, 1.11; 95% confidence interval, 0.74-1.65; P=0.62). We found no evidence that AED use (predominantly levetiracetam) is independently associated with poor outcome. A prospective study is required to assess for a more modest effect of AED use on outcome after ICH.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.222 Epilepsy & Seizures; 1.222.143 Epilepsy
Web Of Science research areas: Clinical Neurology; Peripheral Vascular Disease
ESI research areas: Neuroscience & Behavior

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Title: Prophylactic Antiepileptic Drug Use and Outcome in the Ethnic/Racial Variations of Intracerebral Hemorrhage Study
Creators: Kevin N Sheth - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.). kevin.sheth@yale.edu
Sharyl R Martini - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Charles J Moomaw - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Sebastian Koch - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Mitchell S V Elkind - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Gene Sung - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Steven J Kittner - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Michael Frankel - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Jonathan Rosand - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Carl D Langefeld - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Mary E Comeau - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Salina P Waddy - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Jennifer Osborne - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Daniel Woo - From the Department of Neurology, Yale University School of Medicine, New Haven, CT (K.N.S.); Department of Neurology, Baylor College of Medicine, Houston, TX (S.R.M.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (C.J.M., J.O., D.W.); Department of Neurology, University of Miami School of Medicine, Miami, FL (S.K.); Department of Neurology, College of Physicians and Surgeons, Columbia University, New York (M.S.V.E.); Department of Neurology, University of Southern California, Los Angeles (G.S.); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (S.J.K.); Department of Neurology, Emory University School of Medicine, Atlanta, GA (M.F.); Department of Neurology, Massachusetts General Hospital, Boston, MA (J.R.); Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (C.D.L., M.E.C.); and Office of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.)
Publication Details: Stroke (1970), Vol.46(12), pp.3532-3535
Publisher: United States
Grant note: UL1 TR001425 / NCATS NIH HHS U01 NS069763 / NINDS NIH HHS
Academic Unit: Miller School of Medicine; UMMG Department of Neurology; UMMG Dept of Neurology - Stroke Div
Language: English
Resource Type: Journal article
PMID: 26470777
PMCID: PMC4659755
Record Identifier: 991031575944302976