Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy

Sarah J Lincoln; Owen A Ross; Nicole M Milkovic; Dennis W Dickson; Alex Rajput; Christopher A Robinson; Spiridon Papapetropoulos; Deborah C Mash; Matthew J Farrer

doi:10.1016/j.parkreldis.2006.12.005

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Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy

Journal article

Open access

Peer reviewed

Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy

Sarah J Lincoln, Owen A Ross, Nicole M Milkovic, Dennis W Dickson, Alex Rajput, Christopher A Robinson, Spiridon Papapetropoulos, Deborah C Mash and Matthew J Farrer

Parkinsonism & related disorders, Vol.13(6), pp.340-342

2007

DOI: https://doi.org/10.1016/j.parkreldis.2006.12.005

PMID: 17291816

Abstract

Multiple system atrophy

α-Synuclein

Genomic multiplication

Quantitative PCR

Multiple system atrophy (MSA) is by nature a ‘sporadic’ disease with no evidence of familial aggregation observed. However, the α-synuclein locus ( SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.67 Parkinson's Disease
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior

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Details

Title: Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy
Creators: Sarah J Lincoln - Department of Neuroscience, Molecular Genetics Laboratory and Core, Morris K. Udall Parkinson's Disease Research Center of Excellence, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Owen A Ross - Department of Neuroscience, Molecular Genetics Laboratory and Core, Morris K. Udall Parkinson's Disease Research Center of Excellence, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Nicole M Milkovic - Department of Neuroscience, Molecular Genetics Laboratory and Core, Morris K. Udall Parkinson's Disease Research Center of Excellence, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Dennis W Dickson - Department of Pathology, Mayo Clinic College of Medicine, Jacksonville, FL, USA
Alex Rajput - Division of Neurology, University of Saskatchewan and Saskatoon Health Region, Saskatoon, Sask., Canada
Christopher A Robinson - Department of Pathology, University of Saskatchewan and Saskatoon Health Region, Saskatoon, Sask., Canada
Spiridon Papapetropoulos - Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA
Deborah C Mash - Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA
Matthew J Farrer - Department of Neuroscience, Molecular Genetics Laboratory and Core, Morris K. Udall Parkinson's Disease Research Center of Excellence, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Publication Details: Parkinsonism & related disorders, Vol.13(6), pp.340-342
Publisher: Elsevier Ltd
Academic Unit: UMMG Department of Neurology
Language: English
Resource Type: Journal article
PMID: 17291816
Record Identifier: 991031576728702976