RGS6, but Not RGS4, Is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate

N. Wydeven; E. Posokhova; Z. Xia; K.A. Martemyanov; K. Wickman

doi:10.1074/jbc.M113.520742

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RGS6, but Not RGS4, Is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate

Journal article

Open access

RGS6, but Not RGS4, Is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate

N. Wydeven, E. Posokhova, Z. Xia, K.A. Martemyanov and K. Wickman

Journal of Biological Chemistry, Vol.289(4), pp.2440-2449

2014

DOI: https://doi.org/10.1074/jbc.M113.520742

PMID: 24318880

Abstract

Animals

Carbachol

Cardiotonic Agents

GTP-Binding Protein beta Subunits

Heart Rate

Mice

Mice, Knockout

Muscle Proteins

Parasympathetic Nervous System

Potassium Channels

Receptor, Muscarinic M2

RGS Proteins

Sinoatrial Node

Ablation

Heart

G Proteins

Gene Knockout

GIRK/Kir3

Heart

Muscarinic

Patch Clamp Electrophysiology

Potassium Channels

RGS Proteins

Sinoatrial Node

benzyloxycarbonylleucylleucylleucinal

carbachol

RGS protein

RGS4 protein

RGS6 protein

unclassified drug

G protein

Heart rates

Mouse heart

animal cell

animal experiment

animal tissue

article

chronotropism

concentration (parameters)

controlled study

heart perfusion

heart rate variability

molecular probe

mouse

neuromodulation

nonhuman

parasympathetic tone

phenotypic variation

priority journal

protein expression

resting heart rate

sensitivity analysis

signal transduction

steady state

Proteins

Background: RGS4 and RGS6 are regulator ofGprotein signaling (RGS) proteins, and both have been proposed to modulate parasympathetic regulation of heart rate (HR). Results: RGS6 ablation enhances parasympathetic influence on the heart; RGS4 ablation does not. Conclusion: RGS6 is the primary RGS modulator of parasympathetic influence on the heart. Significance: Understanding the parasympathetic regulation of HR will improve treatment of arrhythmias. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.159 Membrane Channels & Receptors; 1.159.426 GPCR Signaling
Web Of Science research areas: Biochemistry & Molecular Biology
ESI research areas: Biology & Biochemistry

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Title: RGS6, but Not RGS4, Is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate
Creators: N. Wydeven - University of Minnesota
E. Posokhova - Scripps Research Institute
Z. Xia - University of Minnesota
K.A. Martemyanov - Scripps Research Institute
K. Wickman - University of Minnesota
Publication Details: Journal of Biological Chemistry, Vol.289(4), pp.2440-2449
Grant note: National Institutes of Health: HL105550, MH061933, DA007234
This work was supported, in whole or in part, by National Institutes of Health Grants HL105550 (to K. W. and K. A. M.), MH061933 (to K. W.), and DA007234 (to N. W.).
Comment: Export Date: 24 October 2025; Cited By: 33; CODEN: JBCHA
Academic Unit: Physiology and Biophysics Research; Miller School of Medicine
Resource Type: Journal article
PMID: 24318880
Record Identifier: 991032828756902976