Sign in
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
Journal article   Open access  Peer reviewed

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

Andrew L Wolfe, Kamini Singh, Yi Zhong, Philipp Drewe, Vinagolu K Rajasekhar, Viraj R Sanghvi, Konstantinos J Mavrakis, Man Jiang, Justine E Roderick, Joni Van der Meulen, …
Nature (London), Vol.513(7516), pp.65-70
2014-09-04
PMCID: PMC4492470
PMID: 25079319

Abstract

5' Untranslated Regions - genetics Animals Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Base Sequence Cell Line, Tumor Epigenesis, Genetic Eukaryotic Initiation Factor-4A - metabolism Female G-Quadruplexes Humans Mice Mice, Inbred C57BL Nucleotide Motifs Oncogene Proteins - biosynthesis Oncogene Proteins - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Protein Biosynthesis - drug effects Ribosomes - metabolism Transcription Factors - metabolism Transcription, Genetic - drug effects Transcription, Genetic - genetics Triterpenes - pharmacology
url
https://doi.org/10.1038/nature13485View
Published (Version of record) Open

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
International collaboration
Citation topics
1 Clinical & Life Sciences
1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis
1.25.803 mTOR
Web Of Science research areas
Biochemistry & Molecular Biology
ESI research areas
Molecular Biology & Genetics

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Details