Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Ying Guo; Hui Yang; Shi Chen; Peng Zhang; Rong Li; Stephen D Nimer; J William Harbour; Mingjiang Xu; Feng-Chun Yang

doi:10.1038/s41375-018-0126-9

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Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Journal article

Open access

Peer reviewed

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Ying Guo, Hui Yang, Shi Chen, Peng Zhang, Rong Li, Stephen D Nimer, J William Harbour, Mingjiang Xu and Feng-Chun Yang

Leukemia, Vol.32(8), pp.1834-1837

2018-08

DOI: https://doi.org/10.1038/s41375-018-0126-9

PMCID: PMC6168429

PMID: 29743720

Abstract

Leukemia, Experimental - pathology

Leukemia, Experimental - prevention & control

Humans

Leukemia, Myeloid - genetics

Repressor Proteins - genetics

Mice, Transgenic

Gene Expression Regulation, Leukemic

Leukemia, Myeloid - pathology

Leukemia, Myeloid - prevention & control

Animals

Cell Transformation, Neoplastic

Tumor Suppressor Proteins - deficiency

Ubiquitin Thiolesterase - deficiency

Mice

Mutation

Repressor Proteins - metabolism

Leukemia, Experimental - genetics

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https://doi.org/10.1038/s41375-018-0126-9View

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.103 Blood Disorders; 1.103.155 Acute Myeloid Leukemia
Web Of Science research areas: Hematology; Oncology
ESI research areas: Clinical Medicine

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Details

Title: Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo
Creators: Ying Guo - Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA
Hui Yang - Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA
Shi Chen - Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA
Peng Zhang - Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA
Rong Li - Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA
Stephen D Nimer - Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA
J William Harbour - Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA
Mingjiang Xu - Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA. mxx51@miami.edu
Feng-Chun Yang - Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA. fxy37@med.miami.edu
Publication Details: Leukemia, Vol.32(8), pp.1834-1837
Publisher: England
Grant note: P30 EY014801 / NEI NIH HHS R01 HL112294 / NHLBI NIH HHS R21 CA185751 / NCI NIH HHS R01 CA166835 / NCI NIH HHS R01 CA125970 / NCI NIH HHS R01 CA172408 / NCI NIH HHS
Academic Unit: Leadership Department; Miller School of Medicine; Sylvester Comprehensive Cancer Center; UMMG Department of Ophthalmology
Language: English
Resource Type: Journal article
PMID: 29743720
PMCID: PMC6168429
Record Identifier: 991031577431402976