Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients

Matej Skorvanek; Pablo Martinez-Martin; Norbert Kovacs; Ivan Zezula; Mayela Rodriguez-Violante; Jean-Christophe Corvol; Pille Taba; Klaus Seppi; Oleg Levin; Anette Schrag; Iciar Aviles-Olmos; Mario Alvarez-Sanchez; Tomoko Arakaki; Zsuzsanna Aschermann; Eve Benchetrit; Charline Benoit; Alberto Bergareche-Yarza; Amin Cervantes-Arriaga; Anabel Chade; Florence Cormier; Veronika Datieva; David A Gallagher; Nelida Garretto; Zuzana Gdovinova; Oscar Gershanik; Milan Grofik; Vladimir Han; Liis Kadastik-Eerme; Monica M Kurtis; Graziella Mangone; Juan Carlos Martinez-Castrillo; Amelia Mendoza-Rodriguez; Michal Minar; Henry P Moore; Mari Muldmaa; Christoph Mueller; Bernadette Pinter; Werner Poewe; Karin Rallmann; Eva Reiter; Carmen Rodriguez-Blazquez; Carlos Singer; Peter Valkovic; Christopher G Goetz; Glenn T Stebbins

doi:10.1016/j.parkreldis.2018.03.027

Back

Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients

Journal article

Open access

Peer reviewed

Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients

Matej Skorvanek, Pablo Martinez-Martin, Norbert Kovacs, Ivan Zezula, Mayela Rodriguez-Violante, Jean-Christophe Corvol, Pille Taba, Klaus Seppi, Oleg Levin, Anette Schrag, …

Parkinsonism & related disorders, Vol.52, pp.83-89

2018-07

DOI: https://doi.org/10.1016/j.parkreldis.2018.03.027

PMID: 29625875

Abstract

Quality of Life

Non-motor symptoms

Parkinson's disease

Activities of daily living

MDS-UPDRS

The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients. We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items. A total of 3206 PD patients were included in the study. In the first regression analysis, PDQ8 was significantly related to MDS-UPDRS parts I and II, but not to III and IV. In the second regression model, significant contributions to PDQ8 were found for Part I items Fatigue, Pain, Depressed mood, Apathy; and Part II items Dressing, Doing hobbies, Freezing, Speech and Tremor. In the LASSO analysis, six Part I, seven Part II, three Part III and one Part IV items contributed to PDQ8 scores. The five items most significantly related to the model were Depressed mood, Dressing, Apathy, Pain and Fatigue. This is so far the largest study related to HRQoL issues in PD. Restrictions in activities of daily living and non-motor symptoms significantly contribute to HRQoL in PD. •This is the largest study related to Quality of Life (QoL) in PD so far.•QoL is related especially to MDS-UPDRS Part II (ADLs) and Part I (NMS).•Four out of five most important independent contributors were non-motor items.

Files and links (1)

url

https://doi.org/10.1016/j.parkreldis.2018.03.027View

Published (Version of record) Open

Metrics

6 Record Views

45 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.67 Parkinson's Disease
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients
Creators: Matej Skorvanek - Dept. of Neurology, P. J. Safarik University, Kosice, Slovak Republic
Pablo Martinez-Martin - National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain
Norbert Kovacs - Dept. of Neurology, University of Pécs, Pécs, Hungary
Ivan Zezula - Inst. of Mathematics, P. J. Safarik University, Kosice, Slovak Republic
Mayela Rodriguez-Violante - Movement Disorders Unit, Instituto Nacional de Neurologia y Neurocirugia, Mexico DF, Mexico
Jean-Christophe Corvol - Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS_1127, CIC_1422, CNRS UMR_7225, AP-HP, ICM, Hôpital Pitié-Salpêtrière, Département des maladies du système nerveux, F-75013, Paris, France
Pille Taba - Dept. of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia
Klaus Seppi - Dep. of Neurology, Medical University of Innsbruck, Innsbruck, Austria
Oleg Levin - Dept. of Neurology, Russian Medical Academy of Postgraduate Education, Moscow, Russia
Anette Schrag - Dept. of Clinical Neuroscience, UCL Institute of Neurology, London, UK
Iciar Aviles-Olmos - Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK
Mario Alvarez-Sanchez - Dept. of Movement Disorders and Neurodegeneration, CIREN, La Habana, Cuba
Tomoko Arakaki - Dept. of Neurology, Hospital Ramos Mejia, Buenos Aires, Argentina
Zsuzsanna Aschermann - Dept. of Neurology, University of Pécs, Pécs, Hungary
Eve Benchetrit - Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS_1127, CIC_1422, CNRS UMR_7225, AP-HP, ICM, Hôpital Pitié-Salpêtrière, Département des maladies du système nerveux, F-75013, Paris, France
Charline Benoit - Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS_1127, CIC_1422, CNRS UMR_7225, AP-HP, ICM, Hôpital Pitié-Salpêtrière, Département des maladies du système nerveux, F-75013, Paris, France
Alberto Bergareche-Yarza - Dept. of Neurology, Donostia Hospital, Biodonostia Institute and CIBERNED, Sen Sebastian, Spain
Amin Cervantes-Arriaga - Clinical Neurodegenerative Diseases Research Unit, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
Anabel Chade - Movement Disorders Unit, Institute of Neurosciences, Favaloro University, INECO, Buenos Aires, Argentina
Florence Cormier - Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS_1127, CIC_1422, CNRS UMR_7225, AP-HP, ICM, Hôpital Pitié-Salpêtrière, Département des maladies du système nerveux, F-75013, Paris, France
Veronika Datieva - Dept. of Neurology, Russian Medical Academy of Postgraduate Education, Moscow, Russia
David A Gallagher - Barts Health NHS Trust, The Royal London Hospital, London, UK
Nelida Garretto - Dept. of Neurology, Hospital Ramos Mejia, Buenos Aires, Argentina
Zuzana Gdovinova - Dept. of Neurology, P. J. Safarik University, Kosice, Slovak Republic
Oscar Gershanik - Movement Disorders Unit, Institute of Neurosciences, Favaloro University, INECO, Buenos Aires, Argentina
Milan Grofik - Dept. of Neurology, Comenius University, Martin, Slovak Republic
Vladimir Han - Dept. of Neurology, P. J. Safarik University, Kosice, Slovak Republic
Liis Kadastik-Eerme - Dept. of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia
Monica M Kurtis - Movement Disorders Program, Dept. of Neurology, Hospital Ruber Internacional, Madrid, Spain
Graziella Mangone - Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS_1127, CIC_1422, CNRS UMR_7225, AP-HP, ICM, Hôpital Pitié-Salpêtrière, Département des maladies du système nerveux, F-75013, Paris, France
Juan Carlos Martinez-Castrillo - Movement Disorders Unit, Dept. of Neurology, Hospital Ramon y Cajal, IRYCIS, Madrid, Spain
Amelia Mendoza-Rodriguez - Department of Neurology, Complejo Asistencial de Segovia, Segovia, Spain
Michal Minar - 2nd Dept. of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic
Henry P Moore - Dept. of Neurology, University of Miami, Miami, FL, USA
Mari Muldmaa - Dept. of Neurology, North Estonian Medical Center, Tallinn, Estonia
Christoph Mueller - Dep. of Neurology, Medical University of Innsbruck, Innsbruck, Austria
Bernadette Pinter - Dep. of Neurology, Medical University of Innsbruck, Innsbruck, Austria
Werner Poewe - Dep. of Neurology, Medical University of Innsbruck, Innsbruck, Austria
Karin Rallmann - Dept. of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia
Eva Reiter - Dep. of Neurology, Medical University of Innsbruck, Innsbruck, Austria
Carmen Rodriguez-Blazquez - National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain
Carlos Singer - Dept. of Neurology, University of Miami, Miami, FL, USA
Peter Valkovic - 2nd Dept. of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic
Christopher G Goetz - Dept. of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Glenn T Stebbins - Dept. of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Publication Details: Parkinsonism & related disorders, Vol.52, pp.83-89
Publisher: Elsevier Ltd
Academic Unit: Miller School of Medicine; UMMG Department of Neurology
Language: English
Resource Type: Journal article
PMID: 29625875
Record Identifier: 991031577340302976