Replacement of polyps with type 1 macular neovascularization in polypoidal choroidal vasculopathy imaged with swept source OCT angiography

Mengxi Shen; Qiyu Bo; Minlu Song; Xiaoshuang Jiang; Zohar Yehoshua; Giovanni Gregori; Xiaodong Sun; Fenghua Wang; Philip J Rosenfeld

doi:10.1016/j.ajoc.2021.101057

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Replacement of polyps with type 1 macular neovascularization in polypoidal choroidal vasculopathy imaged with swept source OCT angiography

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Replacement of polyps with type 1 macular neovascularization in polypoidal choroidal vasculopathy imaged with swept source OCT angiography

Mengxi Shen, Qiyu Bo, Minlu Song, Xiaoshuang Jiang, Zohar Yehoshua, Giovanni Gregori, Xiaodong Sun, Fenghua Wang and Philip J Rosenfeld

American journal of ophthalmology case reports, Vol.22, p.101057

2021-06

DOI: https://doi.org/10.1016/j.ajoc.2021.101057

PMID: 33796797

Abstract

Polypoidal choroidal vasculopathy

Anti-vascular endothelial growth factor treatment

Type 1 macular neovascularization

Swept source OCT angiography

Polyp

To investigate the morphological changes of polyps in eyes with polypoidal choroidal vasculopathy (PCV) after treatment with vascular endothelial growth factor (VEGF) inhibitors using swept source optical coherence tomography angiography (SS-OCTA). Following anti-VEGF therapy, polyps were found to evolve into typical type 1 macular neovascularization (MNV) in five eyes. In all of these five eyes, a polypoidal lesion was detected adjacent to a serous or hemorrhagic retinal pigment epithelial detachment (PED). Polypoidal lesions in PCV can evolve into typical type 1 MNV. This morphological evolution suggests that these polyps are clusters of tangled vessels that can proliferate into a more typical neovascular pattern, and this evolution may be facilitated by being adjacent to a PED. Since this morphological appearance could be associated with a better prognosis, SS-OCTA might be helpful in identifying cases of transformed polyps that may be associated with a decreased risk for vision loss.

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Title: Replacement of polyps with type 1 macular neovascularization in polypoidal choroidal vasculopathy imaged with swept source OCT angiography
Creators: Mengxi Shen - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
Qiyu Bo - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Minlu Song - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Xiaoshuang Jiang - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
Zohar Yehoshua - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
Giovanni Gregori - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
Xiaodong Sun - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Fenghua Wang - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Philip J Rosenfeld - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
Publication Details: American journal of ophthalmology case reports, Vol.22, p.101057
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; Bascom Palmer Eye Institute; UMMG Department of Ophthalmology
Language: English
Resource Type: Journal article
PMID: 33796797
Record Identifier: 991031577201802976