Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies

Rong Li; Ming-Jiang Xu; Feng-Chun Yang; Yuan Zhou

doi:10.3881/j.issn.1000-503X.2016.05.017

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Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies

Journal article

Peer reviewed

Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies

Rong Li, Ming-Jiang Xu, Feng-Chun Yang and Yuan Zhou

Zhōngguó yīxué kēxuéyuàn xuébào, Vol.38(5), pp.583-588

2016-10-10

DOI: https://doi.org/10.3881/j.issn.1000-503X.2016.05.017

PMID: 27825418

Abstract

5-Methylcytosine - analogs & derivatives

5-Methylcytosine - metabolism

DNA-Binding Proteins - genetics

Hematologic Neoplasms - genetics

Humans

Mutation

Proto-Oncogene Proteins - genetics

TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review,the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.

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Title: Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies
Creators: Rong Li - State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Disease Hospital,CAMS and PUMC,Tianjin 300020,China
Ming-Jiang Xu - State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Disease Hospital,CAMS and PUMC,Tianjin 300020,China
Feng-Chun Yang - State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Disease Hospital,CAMS and PUMC,Tianjin 300020,China
Yuan Zhou - State Key Laboratory of Experimental Hematology,Institute of Hematology and Blood Disease Hospital,CAMS and PUMC,Tianjin 300020,China
Publication Details: Zhōngguó yīxué kēxuéyuàn xuébào, Vol.38(5), pp.583-588
Language: English
Resource Type: Journal article
PMID: 27825418
Record Identifier: 991031613548802976