Response to Comment on "Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior"

Andrea Ganna; Karin J H Verweij; Michel G Nivard; Robert Maier; Robbee Wedow; Alexander S Busch; Abdel Abdellaoui; Shengru Guo; J Fah Sathirapongsasuti; Paul Lichtenstein; Sebastian Lundström; Niklas Långström; Adam Auton; Kathleen Mullan Harris; Gary W Beecham; Eden R Martin; Alan R Sanders; John R B Perry; Benjamin M Neale; Brendan P Zietsch; 23andMe Research Team

doi:10.1126/science.aba5693

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Response to Comment on "Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior"

Journal article

Open access

Peer reviewed

Response to Comment on "Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior"

Andrea Ganna, Karin J H Verweij, Michel G Nivard, Robert Maier, Robbee Wedow, Alexander S Busch, Abdel Abdellaoui, Shengru Guo, J Fah Sathirapongsasuti, Paul Lichtenstein, …

Science (American Association for the Advancement of Science), Vol.371(6536), p.eaba5693

2021-03-26

DOI: https://doi.org/10.1126/science.aba5693

PMID: 33766859

Abstract

Genome-Wide Association Study

Sexual Behavior

Humans

Problem Solving

Hamer argue that the variable "ever versus never had a same-sex partner" does not capture the complexity of human sexuality. We agree and said so in our paper. But Hamer neglect to mention that we also reported follow-up analyses showing substantial overlap of the genetic influences on our main variable and on more nuanced measures of sexual behavior, attraction, and identity.

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 6 Social Sciences; 6.178 Gender & Sexuality Studies; 6.178.483 LGBTQ+
Web Of Science research areas: Social Sciences, Interdisciplinary
ESI research areas: Psychiatry/Psychology

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Details

Title: Response to Comment on "Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior"
Creators: Andrea Ganna - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Karin J H Verweij - Department of Psychiatry, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
Michel G Nivard - Department of Biological Psychology, VU University, 1081 BT Amsterdam, Netherlands
Robert Maier - Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Robbee Wedow - Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
Alexander S Busch - International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, Copenhagen, Denmark
Abdel Abdellaoui - Department of Psychiatry, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
Shengru Guo - Department of Human Genetics, University of Miami, Miami, FL 33136, USA
J Fah Sathirapongsasuti - 23andMe Inc., Mountain View, CA 94041, USA
Paul Lichtenstein - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Sebastian Lundström - Centre for Ethics, Law and Mental Health, University of Gothenburg, Gothenburg, Sweden
Niklas Långström - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Adam Auton - 23andMe Inc., Mountain View, CA 94041, USA
Kathleen Mullan Harris - Department of Sociology, University of North Carolina, Chapel Hill, NC, USA
Gary W Beecham - Department of Human Genetics, University of Miami, Miami, FL 33136, USA
Eden R Martin - Department of Human Genetics, University of Miami, Miami, FL 33136, USA
Alan R Sanders - Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
John R B Perry - MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK
Benjamin M Neale - Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Brendan P Zietsch - Centre for Psychology and Evolution, School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia. zietsch@psy.uq.edu.au
23andMe Research Team
Publication Details: Science (American Association for the Advancement of Science), Vol.371(6536), p.eaba5693
Academic Unit: Miller School of Medicine; John P. Hussman Institute for Human Genomics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 33766859
Record Identifier: 991031599555802976