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Retinal Ganglion Cell Dysfunction in Asymptomatic G11778A: Leber Hereditary Optic Neuropathy
Journal article   Open access  Peer reviewed

Retinal Ganglion Cell Dysfunction in Asymptomatic G11778A: Leber Hereditary Optic Neuropathy

John Guy, William J Feuer, Vittorio Porciatti, Joyce Schiffman, Fawzi Abukhalil, Ruth Vandenbroucke, Potyra R Rosa and Byron L Lam
Investigative ophthalmology & visual science, Vol.55(2), pp.841-848
2014-02
DOI: https://doi.org/10.1167/iovs.13-13365
PMCID: PMC3920864
PMID: 24398093

Abstract

electrophysiology Leber hereditary optic neuropathy mitochondrial DNA
Approximately, half the men and 10% of women who have mutated G11778A mitochondrial DNA will eventually lose vision. No testing is capable of predicting who will develop the phenotype. Here we show that progressive declines in the PERG identify early RGC dysfunction in asymptomatic eyes.
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https://doi.org/10.1167/iovs.13-13365View
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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.197 Molecular & Cell Biology - Mitochondria
1.197.564 Mitochondrial DNA
Web Of Science research areas
Ophthalmology
ESI research areas
Clinical Medicine

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