Abstract
Right (RV) and left ventricular (LV) diastolic function was evaluated in 50 patients with mild, uncomplicated essential hypertension using pulsed-wave Doppler echocardiography. Patients with pulmonary, valvular or coronary artery disease were excluded and antihypertensive drugs were discontinued for the 2 weeks preceding the study. Ten normotensive patients without heart disease acted as control subjects. In the hypertensive patients, RV peak velocity of atrial filling was higher (42 ± 10 vs 31 ± 7 cm/s, p < 0.01) and deceleration half-time was prolonged (96 ± 20 vs 83 ± 10 ms, difference not significant); ratio of early/atrial filling velocity (1.1 ± 0.3 vs 1.7 ± 0.4, p < 0.001) and peak filling rate corrected to stroke volume (3.6 ± 0.7 vs S.3 ± 0.9 SV/s, p < 0.001) were lower. LV filling parameters showed similar changes. RV filling parameters did not correlate with age, LV mass or septal thickness but correlated weakly with LV radius/thickness ratio. There was good correlation between RV and the following corresponding LV filling parameters: peak filling rate, r = 0.68, p < 0.001; ratio of early/atrial filling, r = 0.88, p < 0.0001; and deceleration half-time, r = 0.62, p < 0.001. Data indicate that RV diastolic function is abnormal in essential hypertension and these abnormalities are closely related to those of LV diastolic function.
