SEASONALITY, PARASITE DIVERSITY, AND LOCAL EXTINCTIONS IN PLASMODIUM FALCIPARUM MALARIA

F. Ellis McKenzie; Gerry F Killeen; John C Beier; William H Bossert

doi:10.1890/0012-9658(2001)082[2673:SPDALE]2.0.CO;2

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SEASONALITY, PARASITE DIVERSITY, AND LOCAL EXTINCTIONS IN PLASMODIUM FALCIPARUM MALARIA

Journal article

Open access

Peer reviewed

SEASONALITY, PARASITE DIVERSITY, AND LOCAL EXTINCTIONS IN PLASMODIUM FALCIPARUM MALARIA

F. Ellis McKenzie, Gerry F Killeen, John C Beier and William H Bossert

Ecology (Durham), Vol.82(10), pp.2673-2681

2001

DOI: https://doi.org/10.1890/0012-9658(2001)082[2673:SPDALE]2.0.CO;2

PMCID: PMC2631391

PMID: 19177178

Abstract

host

infection

local extinction

malaria

parasite

seasonal

transmission

vector

We incorporate stochastic, density-dependent seasonal recruitment in adult Anopheles mosquito populations in a discrete-event model of Plasmodium falciparum malaria transmission and find the probabilities of parasite extinction higher than with perennial transmission. Seasonal fluctuations in vector populations act to synchronize the dynamics of infection and immunity in host populations, leading to fluctuations in parasite prevalence greater than expected solely on the basis of high- and low-season vector densities. This synchronization also biases frequencies of infection with multiple parasite phenotypes or genotypes.

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https://doi.org/10.1890/0012-9658(2001)082[2673:SPDALE]2.0.CO;2View

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.217 Parasitology - Malaria, Toxoplasmosis & Coccidiosis; 1.217.59 Malaria
Web Of Science research areas: Ecology
ESI research areas: Environment/Ecology

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Details

Title: SEASONALITY, PARASITE DIVERSITY, AND LOCAL EXTINCTIONS IN PLASMODIUM FALCIPARUM MALARIA
Creators: F. Ellis McKenzie - Department of Organismic and Evolutionary Biology, and Division of Engineering and Applied Sciences, Harvard University, 142 Maxwell-Dworkin Laboratory, 33 Oxford Street, Cambridge, Massachusetts 02138 USA
Gerry F Killeen - Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University Medical Center, 1501 Canal Street, New Orleans, Louisiana 70112 USA
John C Beier - Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University Medical Center, 1501 Canal Street, New Orleans, Louisiana 70112 USA
William H Bossert - Department of Organismic and Evolutionary Biology, and Division of Engineering and Applied Sciences, Harvard University, 142 Maxwell-Dworkin Laboratory, 33 Oxford Street, Cambridge, Massachusetts 02138 USA
Publication Details: Ecology (Durham), Vol.82(10), pp.2673-2681
Academic Unit: Miller School of Medicine; UMMG Department of Public Health Sciences Research
Language: English
Resource Type: Journal article
PMID: 19177178
PMCID: PMC2631391
Record Identifier: 991031615543802976