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SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS
Journal article   Open access  Peer reviewed

SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS

Bing-Yi Chen, Junhong Song, Cheng-Long Hu, Shu-Bei Chen, Qunling Zhang, Chun-Hui Xu, Ji-Chuan Wu, Dan Hou, Ming Sun, Yuan-Liang Zhang, …
Blood, Vol.135(25), pp.2271-2285
2020-06-18
PMID: 32202636

Abstract

Recombinant Proteins - therapeutic use Prognosis Anemia, Refractory, with Excess of Blasts - genetics Tissue Array Analysis Humans Transcriptome Hematopoietic Stem Cells - pathology Histone-Lysine N-Methyltransferase - deficiency Leukemia, Myeloid, Acute - etiology Anemia, Refractory, with Excess of Blasts - metabolism Histone-Lysine N-Methyltransferase - biosynthesis Calgranulin B - physiology Nuclear Pore Complex Proteins - genetics Histone Code - drug effects Time Factors Decitabine - pharmacology Calgranulin B - genetics Hematopoietic Stem Cells - drug effects Calgranulin B - biosynthesis Histone-Lysine N-Methyltransferase - genetics Down-Regulation Mice, Inbred C57BL Cells, Cultured Mice, Transgenic Gene Expression Regulation, Leukemic Homeodomain Proteins - genetics Mice, Knockout Leukemia, Myeloid, Acute - mortality Animals Cell Transformation, Neoplastic Oncogene Proteins, Fusion - genetics Mice Anemia, Refractory, with Excess of Blasts - pathology Myelodysplastic Syndromes - pathology Histone-Lysine N-Methyltransferase - physiology Leukemia, Myeloid, Acute - genetics
url
https://doi.org/10.1182/BLOOD.2019001963View
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Citation topics
1 Clinical & Life Sciences
1.103 Blood Disorders
1.103.155 Acute Myeloid Leukemia
Web Of Science research areas
Hematology
ESI research areas
Clinical Medicine

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