Scc1 (CP0432) and Scc4 (CP0033) function as a type III secretion chaperone for CopN of Chlamydia pneumoniae

Eugenia Silva-Herzog; Sabrina S Joseph; Ann K Avery; Jose A Coba; Katerina Wolf; Kenneth A Fields; Gregory V Plano

doi:10.1128/JB.00203-11

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Scc1 (CP0432) and Scc4 (CP0033) function as a type III secretion chaperone for CopN of Chlamydia pneumoniae

Journal article

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Scc1 (CP0432) and Scc4 (CP0033) function as a type III secretion chaperone for CopN of Chlamydia pneumoniae

Eugenia Silva-Herzog, Sabrina S Joseph, Ann K Avery, Jose A Coba, Katerina Wolf, Kenneth A Fields and Gregory V Plano

Journal of bacteriology, Vol.193(14), pp.3490-3496

2011-07

DOI: https://doi.org/10.1128/JB.00203-11

PMCID: PMC3133303

PMID: 21571996

Abstract

Molecular Chaperones - metabolism

Chlamydophila pneumoniae - metabolism

Bacterial Proteins - chemistry

Bacterial Proteins - genetics

Molecular Chaperones - genetics

Protein Binding

Bacterial Proteins - metabolism

Chlamydophila pneumoniae - chemistry

Chlamydophila pneumoniae - genetics

Molecular Chaperones - chemistry

Amino Acid Motifs

Protein Transport

The Chlamydia pneumoniae CopN protein is a member of the YopN/TyeA/InvE/MxiC family of secreted proteins that function to regulate the secretion of type III secretion system (T3SS) translocator and effector proteins. In this study, the Scc1 (CP0432) and Scc4 (CP0033) proteins of C. pneumoniae AR-39 were demonstrated to function together as a type III secretion chaperone that binds to an N-terminal region of CopN. The Scc1/Scc4 chaperone promoted the efficient secretion of CopN via a heterologous T3SS, whereas, the Scc3 chaperone, which binds to a C-terminal region of CopN, reduced CopN secretion.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.42 Bacteriology; 1.42.1750 Yersinia Pestis
Web Of Science research areas: Microbiology
ESI research areas: Microbiology

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Details

Title: Scc1 (CP0432) and Scc4 (CP0033) function as a type III secretion chaperone for CopN of Chlamydia pneumoniae
Creators: Eugenia Silva-Herzog - Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA
Sabrina S Joseph
Ann K Avery
Jose A Coba
Katerina Wolf
Kenneth A Fields
Gregory V Plano
Publication Details: Journal of bacteriology, Vol.193(14), pp.3490-3496
Publisher: United States
Grant note: AI050552 / NIAID NIH HHS R01 AI050552 / NIAID NIH HHS
Academic Unit: Miller School of Medicine; Microbiology and Immunology Research
Language: English
Resource Type: Journal article
PMID: 21571996
PMCID: PMC3133303
Record Identifier: 991031560825002976