Set-Based Joint Test of Interaction Between SNPs in the VEGF Pathway and Exogenous Estrogen Finds Association With Age-Related Macular Degeneration

Monique D Courtenay; William H Cade; Stephen G Schwartz; Jaclyn L Kovach; Anita Agarwal; Gaofeng Wang; Jonathan L Haines; Margaret A Pericak-Vance; William K Scott

doi:10.1167/iovs.14-14494

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Set-Based Joint Test of Interaction Between SNPs in the VEGF Pathway and Exogenous Estrogen Finds Association With Age-Related Macular Degeneration

Journal article

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Peer reviewed

Set-Based Joint Test of Interaction Between SNPs in the VEGF Pathway and Exogenous Estrogen Finds Association With Age-Related Macular Degeneration

Monique D Courtenay, William H Cade, Stephen G Schwartz, Jaclyn L Kovach, Anita Agarwal, Gaofeng Wang, Jonathan L Haines, Margaret A Pericak-Vance and William K Scott

Investigative ophthalmology & visual science, Vol.55(8), pp.4873-4879

2014-08

DOI: https://doi.org/10.1167/iovs.14-14494

PMCID: PMC4126792

PMID: 25015356

Abstract

epidemiology

case-control study

candidate genes

age-related macular degeneration

statistics

Analysis using a set-based joint test of genetic main effects and environmental interaction found that SNPs in VEGF's proliferation subpathway were associated with neovascular AMD when exogenous estrogen use in women was accounted for.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.36 Ophthalmology; 1.36.212 Retina
Web Of Science research areas: Ophthalmology
ESI research areas: Clinical Medicine

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Details

Title: Set-Based Joint Test of Interaction Between SNPs in the VEGF Pathway and Exogenous Estrogen Finds Association With Age-Related Macular Degeneration
Creators: Monique D Courtenay - Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States
William H Cade - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States
Stephen G Schwartz - Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
Jaclyn L Kovach - Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
Anita Agarwal - Department of Ophthalmology, Vanderbilt University, Nashville, Tennessee, United States
Gaofeng Wang - John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States
Jonathan L Haines - Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States
Margaret A Pericak-Vance - Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States
William K Scott - Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States
Publication Details: Investigative ophthalmology & visual science, Vol.55(8), pp.4873-4879
Publisher: The Association for Research in Vision and Ophthalmology
Academic Unit: Miller School of Medicine; John P. Hussman Institute for Human Genomics; UMMG Department of Ophthalmology; UMMG Dept of Human Genetics - Clinical and Translational Genetics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 25015356
PMCID: PMC4126792
Record Identifier: 991031575641002976