Abstract
BACKGROUND AND OBJECTIVE: To evaluate the impact of sex differences on the presenting features, treatment patterns, and clinical outcomes in patients with central retinal vein occlusions (CRVO).
PATIENTS AND METHODS: This retrospective, longitudinal cohort study included 476 patients diagnosed with CRVO over a 7-year period. Charts were reviewed and clinical data were abstracted.
RESULTS: The average age at CRVO onset was lower in males (63.8 years vs. 66.1 years; P=.048). More males (104/224, 54%) had an ischemic CRVO compared to females (113/252, 45%) at 12 months (P=.05). Males with CRVO had a greater central subfield thickness at the baseline (546.7 +/- 306.8 mu m vs. 438.4 +/- 252.9 mu m; P=.003) and final visits (343 +/- 179.5 mu m vs. 304.6 +/- 176.2 mu m; P=.005). Foveal avascular zone enlargement was more likely in males (39/102, 38% vs. 29/116, 25%; P=.04).
CONCLUSIONS: Sex differences exist in presenting features of patients with CRVO. Further inquiry may help provide individualized recommendations for management of CRVO.
