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Shell crosslinked knedel-like nanoparticles for delivery of cisplatin: effects of crosslinking
Journal article   Peer reviewed

Shell crosslinked knedel-like nanoparticles for delivery of cisplatin: effects of crosslinking

Fuwu Zhang, Mahmoud Elsabahy, Shiyi Zhang, Lily Yun Lin, Jiong Zou and Karen L. Wooley
Nanoscale, Vol.5(8), pp.3220-3225
2013-01-01
DOI: https://doi.org/10.1039/c3nr34320k
PMID: 23474773

Abstract

Chemistry Chemistry, Multidisciplinary Materials Science Materials Science, Multidisciplinary Nanoscience & Nanotechnology Physical Sciences Physics Physics, Applied Science & Technology Science & Technology - Other Topics Technology
Polymeric micelles and shell crosslinked knedel-like (SCK) nano-particles were loaded with up to 48% (w/w) cisplatin. These spherical cisplatin-loaded nanoparticles displayed sustained platinum release over 5 days in PBS, enhanced stability over free cisplatin in aqueous milieu, and significant antitumor activity in vitro against two cancer cell lines.

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Collaboration types
Domestic collaboration
International collaboration
Citation topics
2 Chemistry
2.53 Polymers & Macromolecules
2.53.70 Gene Delivery
Web Of Science research areas
Chemistry, Multidisciplinary
Materials Science, Multidisciplinary
Nanoscience & Nanotechnology
Physics, Applied
ESI research areas
Physics

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