Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin

Hideki Mochizuki; Yuichi Kimura; Kenji Ishii; Keiichi Oda; Toru Sasaki; Manabu Tashiro; Kazuhiko Yanai; Kiichi Ishiwata

doi:10.1016/j.nucmedbio.2004.06.009

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Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin

Journal article

Peer reviewed

Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin

Hideki Mochizuki, Yuichi Kimura, Kenji Ishii, Keiichi Oda, Toru Sasaki, Manabu Tashiro, Kazuhiko Yanai and Kiichi Ishiwata

Nuclear medicine and biology, Vol.31(8), pp.1005-1011

2004

DOI: https://doi.org/10.1016/j.nucmedbio.2004.06.009

PMID: 15607482

Abstract

[ 11C]Doxepin

Histamine H 1 receptor

Static PET scanning

The aim of this study was to develop simplified positron emission tomography measurement using [ 11C]doxepin ([ 11C]DOX) to evaluate histamine H 1 receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ 11C]DOX, estimated quantitatively with a two-compartment model, and the [ 11C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ 11C]DOX–H1R binding.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.159 Membrane Channels & Receptors; 1.159.1806 Histamine
Web Of Science research areas: Radiology, Nuclear Medicine & Medical Imaging
ESI research areas: Clinical Medicine

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Details

Title: Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin
Creators: Hideki Mochizuki - Department of Pharmacology, Tohoku University School of Medicine, Sendai, 980-8575, Japan
Yuichi Kimura - Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, 173-0022, Japan
Kenji Ishii - Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, 173-0022, Japan
Keiichi Oda - Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, 173-0022, Japan
Toru Sasaki - Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, 173-0022, Japan
Manabu Tashiro - Department of Pharmacology, Tohoku University School of Medicine, Sendai, 980-8575, Japan
Kazuhiko Yanai - Department of Pharmacology, Tohoku University School of Medicine, Sendai, 980-8575, Japan
Kiichi Ishiwata - Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, 173-0022, Japan
Publication Details: Nuclear medicine and biology, Vol.31(8), pp.1005-1011
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Dept of Dermatology & Cutaneous Surgery
Language: English
Resource Type: Journal article
PMID: 15607482
Record Identifier: 991031614405102976