Single-dose genome editing therapy rescues auditory and vestibular functions in adult mice with DFNA41 deafness

This work was supported by the NIH (grants R01DC006908, R56DC006908, UG3TR002636, and U01TR005352 to ZYC; R01DC022239, R01DC017264, R01DC005575, andR25 DC020726 to XZL; and R01DC020190, R01DC021795, and R01DC017166 to AAI; the US Department of Defense (grants W81XWH1810331 to ZYC and RH220053-W81XWH-22-HRRP-FRA to XZL) ; and the Fredrick and Ines Yeatts hair cell regeneration fellowship (ZYC) . We thank Jeffery Holt for pointing out the direction of the vestibular function test. We thank Rubina Goharik Simikyan for help setting up vestibular function test (AAI lab) . We thank Haobing Wang at Eaton-Peabody Laboratories for assisting us with Amira bounding box analysis. We thank the Harvard Medical School Electron Microscopy Facility for their help on the scanning electron microscopy imaging. This work is the result of NIH funding, in whole or in part, and is subject to the NIH Public Access Policy. Through acceptance of this federal funding, the NIH has been given a right to make the work publicly available in PubMed Central.r AAI; the US Department of Defense (grants W81XWH1810331 to ZYC and RH220053-W81XWH-22-HRRP-FRA to XZL) ; and the Fredrick and Ines Yeatts hair cell regeneration fellowship (ZYC) . We thank Jeffery Holt for pointing out the direction of the vestibular function test. We thank Rubina Goharik Simikyan for help setting up vestibular function test (AAI lab) . We thank Haobing Wang at Eaton-Peabody Laboratories for assisting us with Amira bounding box analysis. We thank the Harvard Medical School Electron Microscopy Facility for their help on the scanning electron microscopy imaging. This work is the result of NIH funding, in whole or in part, and is subject to the NIH Public Access Policy. Through acceptance of this federal funding, the NIH has been given a right to make the work publicly available in PubMed Central.