Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)

Jatin P Shah; Helena Levyn; Cristina Valero; Dauren Adilbay; Alana Eagan; Junting Zheng; Mithat Gonen; Marc Cohen; Snehal Patel; Ian Ganly; Prathamesh Pai; Paolo Castelnuovo; Fang Ju Gao; Cesare Piazza; Piero Nicolai; Ben Panizza; James Bowman; Catherine Barnett; Luiz P Kowalski; Ronaldo Toledo; Dan M Fliss; John DeAlmeida; Ian Witterick; Philippe Herman; Walter Fontanella; Gregorio Sanchez Aniceto; Sefik Hosal; Serdar Ozer; Subramania Iyer; Richard Harvey; C Rene Leemans; Jan-Jaap Hendrickx; Marcelo Figari; Luis Boccalatte; Ken Ichi Nibu; Peter Clarke; Catherine Rennie; Zhu Yi Ming; Claudio Cernea; Sergio Goncalves; Rodney Schlosser; Fernando Dias; Zoukaa Sargi; Shahzada Ahmed; Wojciech Golusinski; Se Heon Kim; Shirley Y Su; Shaan M Raza; Franco DeMonte; Ehab Hanna

doi:10.1002/hed.27746

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Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)

Journal article

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Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)

Jatin P Shah, Helena Levyn, Cristina Valero, Dauren Adilbay, Alana Eagan, Junting Zheng, Mithat Gonen, Marc Cohen, Snehal Patel, Ian Ganly, …

Head & neck

2024-05-21

DOI: https://doi.org/10.1002/hed.27746

PMID: 38770972

Appears in Miller School of Medicine - Latest Publications

Abstract

global collaboration

multimodality treatment

prognostic factors

skull base tumors

survival outcomes

The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide. A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes. The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor. The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.

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Title: Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)
Creators: Jatin P Shah - Memorial Sloan Kettering Cancer Center
Helena Levyn - Memorial Sloan Kettering Cancer Center
Cristina Valero - Memorial Sloan Kettering Cancer Center
Dauren Adilbay - Memorial Sloan Kettering Cancer Center
Alana Eagan - Memorial Sloan Kettering Cancer Center
Junting Zheng - Memorial Sloan Kettering Cancer Center
Mithat Gonen - Memorial Sloan Kettering Cancer Center
Marc Cohen - Memorial Sloan Kettering Cancer Center
Snehal Patel - Memorial Sloan Kettering Cancer Center
Ian Ganly - Memorial Sloan Kettering Cancer Center
Prathamesh Pai - Tata Memorial Hospital
Paolo Castelnuovo - University of Insubria
Fang Ju Gao - Beijing Tongren Hospital
Cesare Piazza - University of Brescia
Piero Nicolai - University of Brescia
Ben Panizza - Department of Head & Neck Oncology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
James Bowman - Princess Alexandra Hospital
Catherine Barnett - Princess Alexandra Hospital
Luiz P Kowalski - AC Camargo Hospital
Ronaldo Toledo - AC Camargo Hospital
Dan M Fliss - University of Nicosia
John DeAlmeida - University Health Network
Ian Witterick - University Health Network
Philippe Herman - Hôpital Lariboisière
Walter Fontanella - University of Milan
Gregorio Sanchez Aniceto - Research Institute Hospital 12 de Octubre
Sefik Hosal - Atilim University
Serdar Ozer - Atilim University
Subramania Iyer - Amrita Institute of Medical Sciences and Research Centre
Richard Harvey - Sydney Ear Nose Throat Clinic, Darlinghurst, New South Wales, Australia
C Rene Leemans - VU University Amsterdam
Jan-Jaap Hendrickx - VU University Amsterdam
Marcelo Figari - Hospital Italiano de Buenos Aires
Luis Boccalatte - Hospital Italiano de Buenos Aires
Ken Ichi Nibu - Kobe University
Peter Clarke - Imperial College Healthcare NHS Trust
Catherine Rennie - Imperial College Healthcare NHS Trust
Zhu Yi Ming - Peking University Cancer Hospital
Claudio Cernea - Instituto do Câncer do Estado de São Paulo
Sergio Goncalves - Head and Neck Service, ICESP, São Paulo, Brazil
Rodney Schlosser - Medical University of South Carolina
Fernando Dias - Instituto Nacional do Câncer
Zoukaa Sargi - University of Miami
Shahzada Ahmed - NIHR Surgical Reconstruction and Microbiology Research Centre
Wojciech Golusinski - Greater Poland Cancer Center
Se Heon Kim - Yonsei University Health System
Shirley Y Su - The University of Texas MD Anderson Cancer Center
Shaan M Raza - The University of Texas MD Anderson Cancer Center
Franco DeMonte - The University of Texas MD Anderson Cancer Center
Ehab Hanna - The University of Texas MD Anderson Cancer Center
Publication Details: Head & neck
Grant note: P30 CA008748 / NIH HHS
Academic Unit: UMMG Department of Otolaryngology; Miller School of Medicine
Language: English
Resource Type: Journal article
PMID: 38770972
Record Identifier: 991032042202802976