Soluble receptor for advanced glycation end products: a new biomarker in diagnosis and prognosis of chronic inflammatory diseases

Hélène Maillard-Lefebvre; Eric Boulanger; Maïté Daroux; Cédric Gaxatte; Barry I Hudson; Marc Lambert

doi:10.1093/rheumatology/kep199

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Soluble receptor for advanced glycation end products: a new biomarker in diagnosis and prognosis of chronic inflammatory diseases

Journal article

Open access

Soluble receptor for advanced glycation end products: a new biomarker in diagnosis and prognosis of chronic inflammatory diseases

Hélène Maillard-Lefebvre, Eric Boulanger, Maïté Daroux, Cédric Gaxatte, Barry I Hudson and Marc Lambert

Rheumatology (Oxford, England), Vol.48(10), pp.1190-1196

2009-10

DOI: https://doi.org/10.1093/rheumatology/kep199

PMID: 19589888

Abstract

Advanced glycation end products

Biomarker

Receptor for advanced glycation end products

Chronic inflammatory diseases

Atherosclerosis

Inflammation

Soluble form of receptor for advanced glycation end products

The formation of advanced glycation end products (AGEs) is a result of the non-enzymatic reaction between sugars and free amino groups of proteins. AGEs, through interacting with their specific receptor for AGEs (RAGE), result in activation of pro-inflammatory states and are involved in numerous pathologic situations. The soluble form of RAGE (sRAGE) is able to act as a decoy to avoid interaction of RAGE with its pro-inflammatory ligands (AGEs, HMGB1, S100 proteins). sRAGE levels have been found to be decreased in chronic inflammatory diseases including atherosclerosis, diabetes, renal failure and the aging process. The use of measuring circulating sRAGEs may prove to be a valuable vascular biomarker and in this review, we describe the implications of sRAGE in inflammation and propose that this molecule may represent a future therapeutic target in chronic inflammatory diseases.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.16 Phytochemicals; 3.16.614 Advanced Glycation End Products
Web Of Science research areas: Rheumatology
ESI research areas: Clinical Medicine

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Title: Soluble receptor for advanced glycation end products: a new biomarker in diagnosis and prognosis of chronic inflammatory diseases
Creators: Hélène Maillard-Lefebvre - Department of Vascular Aging Biology, Medical School,Department of Internal Medicine, Claude Huriez Hospital,Department of Internal Medicine and Geriatrics, University Hospital of Lille, Lille, France and Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Eric Boulanger - Department of Vascular Aging Biology, Medical School,Department of Internal Medicine, Claude Huriez Hospital,Department of Internal Medicine and Geriatrics, University Hospital of Lille, Lille, France and Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Maïté Daroux - Department of Vascular Aging Biology, Medical School,Department of Internal Medicine, Claude Huriez Hospital,Department of Internal Medicine and Geriatrics, University Hospital of Lille, Lille, France and Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Cédric Gaxatte - Department of Vascular Aging Biology, Medical School,Department of Internal Medicine, Claude Huriez Hospital,Department of Internal Medicine and Geriatrics, University Hospital of Lille, Lille, France and Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Barry I Hudson - Department of Vascular Aging Biology, Medical School,Department of Internal Medicine, Claude Huriez Hospital,Department of Internal Medicine and Geriatrics, University Hospital of Lille, Lille, France and Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Marc Lambert - Department of Vascular Aging Biology, Medical School,Department of Internal Medicine, Claude Huriez Hospital,Department of Internal Medicine and Geriatrics, University Hospital of Lille, Lille, France and Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Publication Details: Rheumatology (Oxford, England), Vol.48(10), pp.1190-1196
Publisher: Oxford University Press
Academic Unit: Cell Biology Research
Language: English
Resource Type: Journal article
PMID: 19589888
Record Identifier: 991031600050202976