Structural Correlation Between the Nerve Fiber Layer and Retinal Ganglion Cell Loss in Mice with Targeted Disruption of the Brn3b Gene

Andrew S Camp; Marco Ruggeri; Gustavo C Munguba; Mary L Tapia; Simon W.M John; Sanjoy K Bhattacharya; Richard K Lee

doi:10.1167/iovs.10-6307

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Structural Correlation Between the Nerve Fiber Layer and Retinal Ganglion Cell Loss in Mice with Targeted Disruption of the Brn3b Gene

Journal article

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Structural Correlation Between the Nerve Fiber Layer and Retinal Ganglion Cell Loss in Mice with Targeted Disruption of the Brn3b Gene

Andrew S Camp, Marco Ruggeri, Gustavo C Munguba, Mary L Tapia, Simon W.M John, Sanjoy K Bhattacharya and Richard K Lee

Investigative ophthalmology & visual science, Vol.52(8), pp.5226-5232

2011-07

DOI: https://doi.org/10.1167/iovs.10-6307

PMCID: PMC3176044

PMID: 21622702

Abstract

Manual segmentation of SD-OCT images allows for the noninvasive characterization of retinal layers in Brn3b knockout mice. Brn3b knockouts have generalized loss of retinal ganglion cells; segmentation results were correlated with histologic cell counts.

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https://doi.org/10.1167/iovs.10-6307View

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.36 Ophthalmology; 1.36.226 Glaucoma
Web Of Science research areas: Ophthalmology
ESI research areas: Clinical Medicine

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Details

Title: Structural Correlation Between the Nerve Fiber Layer and Retinal Ganglion Cell Loss in Mice with Targeted Disruption of the Brn3b Gene
Creators: Andrew S Camp - From the
Marco Ruggeri - From the
Gustavo C Munguba - From the
Mary L Tapia - From the
Simon W.M John - the
Sanjoy K Bhattacharya - From the
Richard K Lee - From the
Publication Details: Investigative ophthalmology & visual science, Vol.52(8), pp.5226-5232
Publisher: Association for Research in Vision and Ophthalmology, Inc
Grant note: NIHP301430 / National Institutes of Health
Academic Unit: Miller School of Medicine; UMMG Department of Ophthalmology
Language: English
Resource Type: Journal article
PMID: 21622702
PMCID: PMC3176044
Record Identifier: 991031559406202976