Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults - United States, March-July 2021

Mark W. Tenforde; Wesley H. Self; Eric A. Naioti; Adit A. Ginde; David J. Douin; Samantha M. Olson; H. Keipp Talbot; Jonathan D. Casey; Nicholas M. Mohr; Anne Zepeski; Manjusha Gaglani; Tresa McNeal; Shekhar Ghamande; Nathan I. Shapiro; Kevin W. Gibbs; D. Clark Files; David N. Hager; Arber Shehu; Matthew E. Prekker; Heidi L. Erickson; Michelle N. Gong; Amira Mohamed; Daniel J. Henning; Jay S. Steingrub; Ithan D. Peltan; Samuel M. Brown; Emily T. Martin; Arnold S. Monto; Akram Khan; Catherine L. Hough; Laurence W. Busse; Caitlin C. ten Lohuis; Abhijit Duggal; Jennifer G. Wilson; Alexandra June Gordon; Nida Qadir; Steven Y. Chang; Christopher Mallow; Carolina Rivas; Hilary M. Babcock; Jennie H. Kwon; Matthew C. Exline; Natasha Halasa; James D. Chappell; Adam S. Lauring; Carlos G. Grijalva; Todd W. Rice; Ian D. Jones; William B. Stubblefield; Adrienne Baughman; Kelsey N. Womack; Christopher J. Lindsell; Kimberly W. Hart; Yuwei Zhu; Meagan Stephenson; Stephanie J. Schrag; Miwako Kobayashi; Jennifer R. Verani; Manish M. Patel; IVY Network Investigators; Hayley Beth Gershengorn

doi:10.15585/MMWR.MM7034E2

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Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults - United States, March-July 2021

Journal article

Open access

Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults - United States, March-July 2021

Mark W. Tenforde, Wesley H. Self, Eric A. Naioti, Adit A. Ginde, David J. Douin, Samantha M. Olson, H. Keipp Talbot, Jonathan D. Casey, Nicholas M. Mohr, Anne Zepeski, …

MMWR. Morbidity and mortality weekly report, Vol.70(34), pp.1156-1162

2021-08-27

DOI: https://doi.org/10.15585/MMWR.MM7034E2

PMID: 34437524

Abstract

Life Sciences & Biomedicine

Public, Environmental & Occupational Health

Science & Technology

What is already known about this topic? COVID-19 mRNA vaccines provide strong protection against severe COVID-19; however, the duration of protection is uncertain. What is added by this report? Among 1,129 patients who received 2 doses of a mRNA vaccine, no decline in vaccine effectiveness against COVID-19 hospitalization was observed over 24 weeks. Vaccine effectiveness was 86% 2-12 weeks after vaccination and 84% at 13-24 weeks. Vaccine effectiveness was sustained among groups at risk for severe COVID-19. What are the implications for public health practice? mRNA vaccine effectiveness against COVID-19-associated hospitalizations was sustained over 24 weeks; ongoing monitoring is needed as new SARS- CoV-2 variants emerge. To reduce hospitalization, all eligible persons should be offered COVID-19 vaccination.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.104 Virology - General; 1.104.1353 Coronavirus
Web Of Science research areas: Public, Environmental & Occupational Health
ESI research areas: Clinical Medicine

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Title: Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults - United States, March-July 2021
Creators: Mark W. Tenforde - Response Biomedical
Wesley H. Self - Vanderbilt University
Eric A. Naioti - Response Biomedical
Adit A. Ginde - University of Colorado Denver
David J. Douin - University of Colorado Denver
Samantha M. Olson - Response Biomedical
H. Keipp Talbot - Vanderbilt University
Jonathan D. Casey - Vanderbilt University
Nicholas M. Mohr - University of Iowa
Anne Zepeski - University of Iowa
Manjusha Gaglani - Texas A&M University
Tresa McNeal - Baylor Medical Center at Garland
Shekhar Ghamande - Baylor Medical Center at Garland
Nathan I. Shapiro - Harvard University
Kevin W. Gibbs - Wake Forest University
D. Clark Files - Wake Forest University
David N. Hager - Johns Hopkins University
Arber Shehu - Johns Hopkins University
Matthew E. Prekker - Hennepin County Medical Center
Heidi L. Erickson - Hennepin County Medical Center
Michelle N. Gong - Yeshiva University
Amira Mohamed - Yeshiva University
Daniel J. Henning - University of Washington
Jay S. Steingrub - Tufts University
Ithan D. Peltan - University of Utah
Samuel M. Brown - University of Utah
Emily T. Martin - University of Michigan–Ann Arbor
Arnold S. Monto - University of Michigan–Ann Arbor
Akram Khan - Oregon Health & Science University
Catherine L. Hough - Oregon Health & Science University
Laurence W. Busse - Emory University
Caitlin C. ten Lohuis - Emory University
Abhijit Duggal - Cleveland Clinic
Jennifer G. Wilson - Stanford University
Alexandra June Gordon - Stanford University
Nida Qadir - University of California, Los Angeles
Steven Y. Chang - University of California, Los Angeles
Christopher Mallow - University of Miami
Carolina Rivas - University of Miami
Hilary M. Babcock - Washington University in St. Louis
Jennie H. Kwon - Washington University in St. Louis
Matthew C. Exline - The Ohio State University
Natasha Halasa - Vanderbilt University
James D. Chappell - Vanderbilt University
Adam S. Lauring - University of Michigan–Ann Arbor
Carlos G. Grijalva - Vanderbilt University
Todd W. Rice - Vanderbilt University
Ian D. Jones - Vanderbilt University
William B. Stubblefield - Vanderbilt University
Adrienne Baughman - Vanderbilt University
Kelsey N. Womack - Vanderbilt University
Christopher J. Lindsell - Vanderbilt University
Kimberly W. Hart - Vanderbilt University
Yuwei Zhu - Vanderbilt University
Meagan Stephenson - Response Biomedical
Stephanie J. Schrag - Yeshiva University
Miwako Kobayashi - Response Biomedical
Jennifer R. Verani - Response Biomedical
Manish M. Patel - Response Biomedical
IVY Network Investigators
Hayley Beth Gershengorn - Miller School of Medicine
Publication Details: MMWR. Morbidity and mortality weekly report, Vol.70(34), pp.1156-1162
Publisher: Centers Disease Control & Prevention
Number of pages: 7
Academic Unit: UMMG Dept of Medicine - Pulmonary, Critical Care & Sleep Medicine; Miller School of Medicine
Language: English
Resource Type: Journal article
PMID: 34437524
Record Identifier: 991031713284502976