Switching Partners in a Regulatory Tango

Kenichi Nishioka; Danny Reinberg

doi:10.1126/science.1067622

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Switching Partners in a Regulatory Tango

Journal article

Peer reviewed

Switching Partners in a Regulatory Tango

Kenichi Nishioka and Danny Reinberg

Science (New York, N.Y.), Vol.294(5551), pp.2497-2498

2001

DOI: https://doi.org/10.1126/science.1067622

Abstract

The coactivator CBP/p300 cooperates with the enzyme CARM1 to boost the activity of the nuclear hormone receptor transcription factors. But what is the relationship between CBP/p300 and CARM1? As Nishioka and Reinberg explain in their Perspective, new work reveals that CARM1 regulates the availability of CBP/p300 by methylating the KIX domain of this coactivator.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.54 Molecular & Cell Biology - Genetics; 1.54.100 DNA Methylation
Web Of Science research areas: Biochemistry & Molecular Biology
ESI research areas: Molecular Biology & Genetics

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Details

Title: Switching Partners in a Regulatory Tango
Creators: Kenichi Nishioka - Howard Hughes Medical Institute
Danny Reinberg - Howard Hughes Medical Institute
Publication Details: Science (New York, N.Y.), Vol.294(5551), pp.2497-2498
Publisher: American Association for the Advancement of Science (AAAS); United States
Academic Unit: Miller School of Medicine; UMMG Dept of Human Genetics - Clinical and Translational Genetics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Resource Type: Journal article
Record Identifier: 991031811773402976