Abstract
The aim of the present study is to prepare and characterize
Naga bhasma
on structural and elemental basis to address the role of the raw materials used during the preparation, compound form of the lead
bhasma
, nature (crystalline/amorphous) and crystallite/particle size of the drug. The study also covers the toxicological effect of the drug on albino rats. It was found that drug contains lead in nano-crystalline (~60 nm) lead sulfide form (Pb
2+
) associated with the organic contents and different nutrient elements coming from the herbs used during the preparation.
Naga bhasma
prepared was found to be totally safe in histopathology study on rats at a dose of 6 mg/100 g/day. The different characterization techniques used present a role model for the quality control and standardization of such kinds of herbo-metallic medicines.
