Abstract
A series of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles were synthesized regioselectively using click chemistry and evaluated at CB1 cannabinoid receptors. The
n-propyl ester (
K
i
=
4.6
nM) exhibited the most potent affinity of the series.
A series of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles were synthesized regioselectively using click chemistry and evaluated at CB1 cannabinoid receptors. The
n-propyl ester
11 (
K
i
=
4.6
nM) and phenyl ester
14 (
K
i
=
11
nM) exhibited the most potent affinity of the series.
