Abstract
A series of 3α-benzyl-8-(diarylmethoxyethyl)-8-azabicyclo[3.2.1]octanes was synthesized and the binding affinities of the compounds were determined at the dopamine transporter. The unsubstituted analogue
7b (
K
i=98
nM) was the most potent compound of the series with binding affinity three-times greater than cocaine and only 5-fold less than GBR-12909. The structure–activity data for
7a–
f suggests that these compounds may be binding at the dopamine transporter in a similar fashion to GBR 12909.
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