TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease

Madison M. Reeves; Anna Calliari; Tiffany W. Todd; Candela Maroto Cidfuentes; Karen Jansen-West; Mei Yue; Yuping Song; Judith Dunmore; Bailey Rawlinson; Erica Engelberg-Cook; Michael DeTure; Gregory S. Day; Neill R. Graff-Radford; Bradley F. Boeve; David S. Knopman; Ronald C. Petersen; Casey N. Cook; Melissa E. Murray; Dennis W. Dickson; Keith A. Josephs; Leonard Petrucelli; Mercedes Prudencio

doi:10.1002/alz.71713

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TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease

Journal article

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TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease

Madison M. Reeves, Anna Calliari, Tiffany W. Todd, Candela Maroto Cidfuentes, Karen Jansen-West, Mei Yue, Yuping Song, Judith Dunmore, Bailey Rawlinson, Erica Engelberg-Cook, …

Alzheimer's & dementia, Vol.22(9), p.e71713

2026-09

DOI: https://doi.org/10.1002/alz.71713

PMID: 42720122

Appears in Miller School of Medicine - Latest Publications

Abstract

AluYb8

Alzheimer's disease

apolipoprotein E

APOE

co-pathologies

genetics

limbic-predominant age-related TDP-43 encephalopathy (LATE)

neurodegenerative disease

transactive response DNA-binding protein 43 (TDP-43)

TMEM106B

Co‐pathologies are highly prevalent in post mortem AD cases.TDP‐43 and vascular lesions are enriched in AD cases with an older age of death. TMEM106B is a selective modulator of TDP‐43 co‐pathology presentation in AD.In contrast to TMEM106B, APOE ε4 is a global modifier of co‐pathology in AD. TMEM106B variants specifically favor AD TDP‐43 pathological subtype α.

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Title: TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease
Creators: Madison M. Reeves - Mayo Clinic in Florida
Anna Calliari - Mayo Clinic in Florida
Tiffany W. Todd - Jacksonville College
Candela Maroto Cidfuentes - Mayo Clinic
Karen Jansen-West - Mayo Clinic in Florida
Mei Yue - Jacksonville College
Yuping Song - Mayo Clinic in Florida
Judith Dunmore - University of Miami
Bailey Rawlinson - Jacksonville College
Erica Engelberg-Cook - Mayo Clinic in Florida
Michael DeTure - Mayo Clinic in Florida
Gregory S. Day - Jacksonville College
Neill R. Graff-Radford - Mayo Clinic in Florida
Bradley F. Boeve - Mayo Clinic
David S. Knopman - Mayo Clinic
Ronald C. Petersen - Mayo Clinic
Casey N. Cook - University of South Florida
Melissa E. Murray - Mayo Clinic in Florida
Dennis W. Dickson - Mayo Clinic in Florida
Keith A. Josephs - Mayo Clinic
Leonard Petrucelli - University of Miami
Mercedes Prudencio - University of Miami
Publication Details: Alzheimer's & dementia, Vol.22(9), p.e71713
Publisher: Wiley; HOBOKEN
Number of pages: 13
Grant note: Cure Alzheimer's Fund Target ALS Foundation Alzheimer's Disease Strategic Fund: ADSF-24-1284327-C BrightFocus Foundation: A2024017S National Institutes of Health: R01NS120992, R01NS132330, U54NS123743, R01AG037491, P30AG062677, U01AG006786, R35NS137447 The Kissick Family Foundation
We would like to thank Matthew C. Baker for his contributions to the genotyping of TMEM106B. We are grateful to all donors and their caregivers. This work was supported by the National Institutes of Health (R01NS120992 to K.A.J. and M.P., R01NS132330 to L.P., U54NS123743 to L.P. and M.P., R01AG037491 to K.A.J., P30AG062677 to B.F.B., U01AG006786 to R.C.P., and R35NS137447 to L.P.), the Target ALS Foundation (to L.P. and M.P.), the BrightFocus Foundation (A2024017S to M.P.), the Alzheimer's Disease Strategic Fund (ADSF-24-1284327-C to L.P.), the Cure Alzheimer's Fund (to L.P.), and the Kissick Family Foundation (to M.P. and L.P.).
Academic Unit: Miller School of Medicine; Biochemistry & Molecular Biology Research
Language: English
Resource Type: Journal article
PMID: 42720122
Record Identifier: 991033191487102976