Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication

Todd M Allen; Lorenzo Mortara; Bianca R Mothé; Max Liebl; Peicheng Jing; Briana Calore; Marian Piekarczyk; Richard Ruddersdorf; David H O'Connor; X Wang; Chenxi Wang; David B Allison; John D Altman; Alessandro Sette; Ronald C Desrosiers; Gerd Sutter; David I Watkins

doi:10.1128/JVI.76.8.4108-4112.2002

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Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication

Journal article

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Peer reviewed

Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication

Todd M Allen, Lorenzo Mortara, Bianca R Mothé, Max Liebl, Peicheng Jing, Briana Calore, Marian Piekarczyk, Richard Ruddersdorf, David H O'Connor, X Wang, …

Journal of virology, Vol.76(8), pp.4108-4112

2002-04

DOI: https://doi.org/10.1128/JVI.76.8.4108-4112.2002

PMCID: PMC136098

PMID: 11907251

Abstract

Vaccines and Antiviral Agents

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV-1
Web Of Science research areas: Virology
ESI research areas: Microbiology

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Details

Title: Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication
Creators: Todd M Allen - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Lorenzo Mortara - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Bianca R Mothé - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Max Liebl - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Peicheng Jing - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Briana Calore - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Marian Piekarczyk - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Richard Ruddersdorf - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
David H O'Connor - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
X Wang - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Chenxi Wang - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
David B Allison - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
John D Altman - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Alessandro Sette - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Ronald C Desrosiers - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Gerd Sutter - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
David I Watkins - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715
Publication Details: Journal of virology, Vol.76(8), pp.4108-4112
Publisher: American Society for Microbiology
Academic Unit: Miller School of Medicine; UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 11907251
PMCID: PMC136098
Record Identifier: 991031600029102976