The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults

Warren D Taylor; Stephan Züchner; Martha E Payne; Denise F Messer; Tracy J Doty; James R MacFall; John L Beyer; K. Ranga R Krishnan

doi:10.1016/j.pscychresns.2007.01.005

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The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults

Journal article

Open access

Peer reviewed

The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults

Warren D Taylor, Stephan Züchner, Martha E Payne, Denise F Messer, Tracy J Doty, James R MacFall, John L Beyer and K. Ranga R Krishnan

Psychiatry research. Neuroimaging, Vol.155(2), pp.173-177

2007

DOI: https://doi.org/10.1016/j.pscychresns.2007.01.005

PMCID: PMC1950247

PMID: 17521892

Abstract

Temporal lobe

Magnetic resonance imaging

Genetic polymorphisms

Hippocampus

We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes.

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Citation topics: 1 Clinical & Life Sciences; 1.21 Psychiatry; 1.21.1519 5-HTTLPR
Web Of Science research areas: Clinical Neurology; Neuroimaging; Psychiatry
ESI research areas: Neuroscience & Behavior

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Details

Title: The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults
Creators: Warren D Taylor - Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
Stephan Züchner - Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
Martha E Payne - Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
Denise F Messer - Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
Tracy J Doty - Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
James R MacFall - Department of Radiology, Duke University Medical Center, Durham, NC, USA
John L Beyer - Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
K. Ranga R Krishnan - Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
Publication Details: Psychiatry research. Neuroimaging, Vol.155(2), pp.173-177
Publisher: Elsevier Ireland Ltd
Academic Unit: Leadership Department; Miller School of Medicine; John P. Hussman Institute for Human Genomics
Language: English
Resource Type: Journal article
PMID: 17521892
PMCID: PMC1950247
Record Identifier: 991031560048002976