The Concentration of Total Nucleated Cells in Harvested Bone Marrow for Transplantation Has Decreased over Time

Nicole L Prokopishyn; Brent R Logan; Deidre M Kiefer; Jennifer A Sees; Pintip Chitphakdithai; Ibrahim A Ahmed; Paolo N Anderlini; Amer M Beitinjaneh; Christopher Bredeson; Jan Cerny; Saurabh Chhabra; Andrew Daly; Miguel Angel Diaz; Nosha Farhadfar; Haydar A Frangoul; Siddhartha Ganguly; Dennis A Gastineau; Usama Gergis; Gregory A Hale; Peiman Hematti; Rammurti T Kamble; Kimberly A Kasow; Hillard M Lazarus; Jane L Liesveld; Hemant S Murthy; Maxim Norkin; Richard F Olsson; Mona Papari; Bipin N Savani; Jeffrey Szer; Edmund K Waller; Baldeep Wirk; Jean A Yared; Michael A Pulsipher; Nirali N Shah; Galen E Switzer; Paul V O'Donnell; Dennis L Confer; Bronwen E Shaw

doi:10.1016/j.bbmt.2019.01.034

Back

The Concentration of Total Nucleated Cells in Harvested Bone Marrow for Transplantation Has Decreased over Time

Journal article

Open access

Peer reviewed

The Concentration of Total Nucleated Cells in Harvested Bone Marrow for Transplantation Has Decreased over Time

Nicole L Prokopishyn, Brent R Logan, Deidre M Kiefer, Jennifer A Sees, Pintip Chitphakdithai, Ibrahim A Ahmed, Paolo N Anderlini, Amer M Beitinjaneh, Christopher Bredeson, Jan Cerny, …

Biology of blood and marrow transplantation, Vol.25(7), pp.1325-1330

2019-07

DOI: https://doi.org/10.1016/j.bbmt.2019.01.034

PMID: 30716454

Abstract

Bone marrow

Unrelated donor

Total nucleated cells

Bone marrow (BM) is an essential source of hematopoietic stem cell grafts for many allogeneic hematopoietic cell transplant (HCT) recipients, including adult patients (for specific diseases and transplantation strategies) and the majority of pediatric recipient. However, since the advent of granulocyte colony-stimulating factor-mobilized peripheral blood stem cell (PBSC) grafts, there has been a significant decrease in the use of BM in HCT, thought to be due mainly to the increased logistical challenges in harvesting BM compared with PBSCs, as well as generally no significant survival advantage of BM over PBSCs. The decreased frequency of collection has the potential to impact the quality of BM harvests. In this study, we examined >15,000 BM donations collected at National Marrow Donor Program centers between 1994 and 2016 and found a significant decline in the quality of BM products, as defined by the concentration of total nucleated cells (TNCs). The mean TNC concentration in BM donations dropped from 21.8 × 106 cells/mL in the earliest era (1994 to 1996) to 18.7 × 106 cells/mL in the most recent era (2012 to 2016) (means ratio, .83; P < .001). This decline in BM quality was seen despite the selection of more donors perceived to be optimal (eg, younger and male). Multivariate regression analysis showed that higher-volume centers (performing >30 collections per era) had better-quality harvests with higher concentrations of TNCs collected. In conclusion, we have identified a significant decrease in the quality of BM collections over time, and lower-volume collection centers had poorer-quality harvests. In this analysis, we could not elucidate the direct cause for this finding, suggesting the need for further studies to investigate the key factors responsible and to explore the impact on transplant recipients.

Files and links (1)

url

https://doi.org/10.1016/j.bbmt.2019.01.034View

Published (Version of record) Open

Metrics

22 Record Views

11 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.103 Blood Disorders; 1.103.380 GvHD
Web Of Science research areas: Hematology; Immunology; Transplantation
ESI research areas: Immunology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: The Concentration of Total Nucleated Cells in Harvested Bone Marrow for Transplantation Has Decreased over Time
Creators: Nicole L Prokopishyn - Department of Pathology and Laboratory Medicine,University of Calgary, Calgary, Alberta, Canada
Brent R Logan - Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin
Deidre M Kiefer - Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, Minnesota
Jennifer A Sees - Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, Minnesota
Pintip Chitphakdithai - Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, Minnesota
Ibrahim A Ahmed - Department of Hematology Oncology and Bone Marrow Transplantation, The Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Paolo N Anderlini - Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
Amer M Beitinjaneh - Department of Hematology, University of Miami, Miami, Florida
Christopher Bredeson - The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada
Jan Cerny - Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts
Saurabh Chhabra - Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin
Andrew Daly - Tom Baker Cancer Center, Calgary, Alberta, Canada
Miguel Angel Diaz - Department of Hematology/Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain
Nosha Farhadfar - Division of Hematology/Oncology, University Florida College of Medicine, Gainesville, Florida
Haydar A Frangoul - Division of Pediatric-Hematology and Oncology, The Children's Hospital at TriStar Centennial and Sarah Cannon Research Institute, Nashville, Tennessee
Siddhartha Ganguly - Division of Hematological Malignancy and Cellular Therapeutics, University of Kansas Health System, Kansas City, Kansas
Dennis A Gastineau - Division of Hematology, Mayo Clinic Rochester, Rochester, Minnesota
Usama Gergis - Hematolgic Malignancies & Bone Marrow Transplant, Department of Medical Oncology, New York Presbyterian Hospital/Weill Cornell Medical College, New York, New York
Gregory A Hale - Department of Hematology/Oncology, Johns Hopkins All Children's Hospital, St. Petersburg, Florida
Peiman Hematti - Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, Wisconsin
Rammurti T Kamble - Division of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas
Kimberly A Kasow - Department of Pediatrics in the Division of Hematology-Oncology, University of North Carolina, Chapel Hill, North Carolina
Hillard M Lazarus - Seidman Cancer Center-University Hospitals Cleveland Medical Center, Cleveland, Ohio
Jane L Liesveld - Strong Memorial Hospital-University of Rochester Medical Center, Rochester, New York
Hemant S Murthy - Division of Hematology/Oncology, University Florida College of Medicine, Gainesville, Florida
Maxim Norkin - Division of Hematology/Oncology, University Florida College of Medicine, Gainesville, Florida
Richard F Olsson - Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden
Mona Papari - ITxM Clinical Services Cord Blood Lab, Rosemont, Illinois
Bipin N Savani - Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
Jeffrey Szer - Clinical Haematology at Peter MacCalluma Cancer Centre and The Royal Melbourne Hospital, Victoria, Australia
Edmund K Waller - Department of Hematology and Meidcal Oncology, Emory University Hospital, Atlanta, Georgia
Baldeep Wirk - Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, Washington
Jean A Yared - Blood & Marrow Transplantation Program, Division of Hematology/Oncology, Department of Medicine, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland
Michael A Pulsipher - Division of Hematology, Oncology, and Blood and Marrow Transplantation, Children's Hospital Los Angeles, USC Keck School of Medicine, Los Angeles, California
Nirali N Shah - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Galen E Switzer - Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
Paul V O'Donnell - Department of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Dennis L Confer - Center for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, Minnesota
Bronwen E Shaw - Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin
Publication Details: Biology of blood and marrow transplantation, Vol.25(7), pp.1325-1330
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Dept of Medicine - Hematology/Oncology
Language: English
Resource Type: Journal article
PMID: 30716454
Record Identifier: 991031597540702976