The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer

Jennifer B Permuth; Kaleena B Dezsi; Shraddha Vyas; Karla N Ali; Toni L Basinski; Ovie A Utuama; Jason W Denbo; Jason Klapman; Aamir Dam; Estrella Carballido; Dae Won Kim; Jose M Pimiento; Benjamin D Powers; Amy K Otto; Jung W Choi; Dung-Tsa Chen; Jamie K Teer; Francisca Beato; Alina Ward; Elena M Cortizas; Suzanne Y Whisner; Iverson E Williams; Andrea N Riner; Kenneth Tardif; Vic Velanovich; Andreas Karachristos; Wade G Douglas; Adrian Legaspi; Bassan J Allan; Kenneth Meredith; Manual A Molina-Vega; Philip Bao; Jamii St Julien; Kevin L Huguet; Lee Green; Folakemi T Odedina; Nagi B Kumar; Vani N Simmons; Thomas J George; Susan T Vadaparampil; Pamela J Hodul; J Pablo Arnoletti; Ziad T Awad; Debashish Bose; Kun Jiang; Barbara A Centeno; Clement K Gwede; Mokenge Malafa; Sarah M Judge; Andrew R Judge; Daniel Jeong; Mark Bloomston; Nipun B Merchant; Jason B Fleming; Jose G Trevino; On Behalf Of The Florida Pancreas Collaborative; Florida Pancreas Collaborative

doi:10.3390/cancers13040809

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The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer

Journal article

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Peer reviewed

The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer

Jennifer B Permuth, Kaleena B Dezsi, Shraddha Vyas, Karla N Ali, Toni L Basinski, Ovie A Utuama, Jason W Denbo, Jason Klapman, Aamir Dam, Estrella Carballido, …

Cancers, Vol.13(4), pp.1-24

2021-02-15

DOI: https://doi.org/10.3390/cancers13040809

PMID: 33671939

Abstract

prospective cohort

underserved populations

biorepository

cancer disparities

Pancreatic Cancer

: Well-annotated, high-quality biorepositories provide a valuable platform to support translational research. However, most biorepositories have poor representation of minority groups, limiting the ability to address health disparities. : We describe the establishment of the Florida Pancreas Collaborative (FPC), the first state-wide prospective cohort study and biorepository designed to address the higher burden of pancreatic cancer (PaCa) in African Americans (AA) compared to Non-Hispanic Whites (NHW) and Hispanic/Latinx (H/L). We provide an overview of stakeholders; study eligibility and design; recruitment strategies; standard operating procedures to collect, process, store, and transfer biospecimens, medical images, and data; our cloud-based data management platform; and progress regarding recruitment and biobanking. : The FPC consists of multidisciplinary teams from fifteen Florida medical institutions. From March 2019 through August 2020, 350 patients were assessed for eligibility, 323 met inclusion/exclusion criteria, and 305 (94%) enrolled, including 228 NHW, 30 AA, and 47 H/L, with 94%, 100%, and 94% participation rates, respectively. A high percentage of participants have donated blood (87%), pancreatic tumor tissue (41%), computed tomography scans (76%), and questionnaires (62%). : This biorepository addresses a critical gap in PaCa research and has potential to advance translational studies intended to minimize disparities and reduce PaCa-related morbidity and mortality.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.151 Pancreas & Gall Bladder Disorders; 1.151.395 Pancreatic Cancer
Web Of Science research areas: Oncology
ESI research areas: Clinical Medicine

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Title: The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer
Creators: Jennifer B Permuth - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Kaleena B Dezsi - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Shraddha Vyas - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Karla N Ali - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Toni L Basinski - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Ovie A Utuama - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Jason W Denbo - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Jason Klapman - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Aamir Dam - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Estrella Carballido - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Dae Won Kim - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Jose M Pimiento - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Benjamin D Powers - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Amy K Otto - Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL 33612, USA
Jung W Choi - Department of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Dung-Tsa Chen - Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Jamie K Teer - Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Francisca Beato - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Alina Ward - Lee Health Regional Cancer Center, Fort Myers, FL 33905, USA
Elena M Cortizas - Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Suzanne Y Whisner - Cancer Institute, Advent Health Orlando, Orlando, FL 32804, USA
Iverson E Williams - College of Medicine, University of Florida, Gainesville, FL 32610, USA
Andrea N Riner - College of Medicine, University of Florida, Gainesville, FL 32610, USA
Kenneth Tardif - Department of Surgery, St. Anthony's Hospital, St. Petersburg, FL 33705, USA
Vic Velanovich - Tampa General Hospital, University of South Florida, Tampa, FL 33606, USA
Andreas Karachristos - Tampa General Hospital, University of South Florida, Tampa, FL 33606, USA
Wade G Douglas - Division of Surgery, Tallahassee Memorial Healthcare, Department of Clinical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32308, USA
Adrian Legaspi - Center for Advanced Surgical Oncology at Palmetto General Hospital, Tenet Healthcare Palmetto General, Hialeah, FL 33016, USA
Bassan J Allan - Lee Health Regional Cancer Center, Fort Myers, FL 33905, USA
Kenneth Meredith - Department of Gastrointestinal Oncology, Brian Jellison Cancer Institute, Sarasota Memorial Hospital, Sarasota, FL 34239, USA
Manual A Molina-Vega - Lakeland Regional Health, Lakeland, FL 33805, USA
Philip Bao - Department of Surgical Oncology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
Jamii St Julien - Department of Surgery, St. Anthony's Hospital, St. Petersburg, FL 33705, USA
Kevin L Huguet - Department of Surgery, St. Anthony's Hospital, St. Petersburg, FL 33705, USA
Lee Green - Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Folakemi T Odedina - Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA
Nagi B Kumar - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Vani N Simmons - Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Thomas J George - Division of Oncology, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
Susan T Vadaparampil - Office of Community Outreach, Engagement, and Equity, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Pamela J Hodul - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
J Pablo Arnoletti - Center for Surgical Oncology, Advent Health Orlando, Orlando, FL 32804, USA
Ziad T Awad - Surgery, University of Florida-Jacksonville, Jacksonville, FL 32209, USA
Debashish Bose - Surgical Oncology, University of Florida-Orlando, Orlando, FL 32806, USA
Kun Jiang - Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Barbara A Centeno - Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Clement K Gwede - Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Mokenge Malafa - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Sarah M Judge - Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA
Andrew R Judge - Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA
Daniel Jeong - Department of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Mark Bloomston - Lee Health Regional Cancer Center, Fort Myers, FL 33905, USA
Nipun B Merchant - Department of Surgical Oncology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Jason B Fleming - Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA
Jose G Trevino - Division of Surgical Oncology, Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, VA 23219, USA
On Behalf Of The Florida Pancreas Collaborative
Florida Pancreas Collaborative
Publication Details: Cancers, Vol.13(4), pp.1-24
Grant note: P30-CA076292 / NCI designated Comprehensive Cancer Center Grant #8JK02 / James and Esther King Biomedical Research Program, Florida Department of Health
Academic Unit: UHealth System - Operations; UMMG Department of Surgery; Miller School of Medicine; UMMG Department of Public Health Sciences Research; UMMG Dept of Surgery - Div of Surgical Oncology; UMHC/SCCC
Language: English
Resource Type: Journal article
PMID: 33671939
Record Identifier: 991031599225502976